103848-61-9

103848-61-9 structure

Name: 6-Maleimidocaproic acid sulfo-NHS
Chemical Name: 1-[6-(2,5-dioxopyrrol-1-yl)hexanoyloxy]-2,5-dioxopyrrolidine-3-sulfonic acid
CAS Number: 103848-61-9
Molecular Formula: C₁₄H₁₆N₂O₉S
Molecular Weight: 388.35000
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2016-07-22 17:32:15
Modify Date: 2025-08-26 13:01:43
6-Maleimidocaproic acid sulfo-NHS is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	1-[6-(2,5-dioxopyrrol-1-yl)hexanoyloxy]-2,5-dioxopyrrolidine-3-sulfonic acid
Synonyms	1H-Pyrrole-1-hexanoicacid,2,5-dihydro-2,5-dioxo-,2,5-dioxo-3-sulfo-1-pyrrolidinyl ester BICL221

Description	6-Maleimidocaproic acid sulfo-NHS is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	Alkyl/ether
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.