6-Maleimidocapronic acid

Modify Date: 2024-01-03 21:27:12

6-Maleimidocapronic acid Structure
6-Maleimidocapronic acid structure
Common Name 6-Maleimidocapronic acid
CAS Number 55750-53-3 Molecular Weight 211.214
Density 1.3±0.1 g/cm3 Boiling Point 407.3±28.0 °C at 760 mmHg
Molecular Formula C10H13NO4 Melting Point 86-91ºC
MSDS Chinese USA Flash Point 200.1±24.0 °C
Symbol GHS05 GHS07
GHS05, GHS07
Signal Word Danger

 Use of 6-Maleimidocapronic acid


6-Maleimidocapronic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 6-Maleimidocaproic Acid
Synonym More Synonyms

 6-Maleimidocapronic acid Biological Activity

Description 6-Maleimidocapronic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

Alkyl-Chain

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 407.3±28.0 °C at 760 mmHg
Melting Point 86-91ºC
Molecular Formula C10H13NO4
Molecular Weight 211.214
Flash Point 200.1±24.0 °C
Exact Mass 211.084457
PSA 74.68000
LogP 0.71
Vapour Pressure 0.0±2.0 mmHg at 25°C
Index of Refraction 1.537
Storage condition 2-8°C

 Safety Information

Symbol GHS05 GHS07
GHS05, GHS07
Signal Word Danger
Hazard Statements H315-H318-H335
Precautionary Statements P261-P280-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi: Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S36
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2925190090

 Synthetic Route

~71%

6-Maleimidocapronic acid Structure

6-Maleimidocapr...

CAS#:55750-53-3

Literature: Dalton Transactions, , # 24 p. 3886 - 3897

~74%

6-Maleimidocapronic acid Structure

6-Maleimidocapr...

CAS#:55750-53-3

Literature: Journal of Medicinal Chemistry, , vol. 56, # 24 p. 9955 - 9968

~30%

6-Maleimidocapronic acid Structure

6-Maleimidocapr...

CAS#:55750-53-3

Literature: EP665020 A3, ;

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6-Maleimidocapronic acid Structure

6-Maleimidocapr...

CAS#:55750-53-3

Literature: US8241655 B2, ;

~%

6-Maleimidocapronic acid Structure

6-Maleimidocapr...

CAS#:55750-53-3

Literature: Dalton Transactions, , # 24 p. 3886 - 3897

 Customs

HS Code 2925190090
Summary 2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

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 Synonyms

6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoic acid
MFCD00043140
1H-Pyrrole-1-hexanoic acid, 2,5-dihydro-2,5-dioxo-
6-(2,5-dioxopyrrol-1-yl)hexanoic acid
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