RETRA

Modify Date: 2024-04-04 13:25:43

RETRA Structure
RETRA structure
Common Name RETRA
CAS Number 1036069-26-7 Molecular Weight 269.34
Density N/A Boiling Point N/A
Molecular Formula C11H11NO3S2 Melting Point N/A
MSDS USA Flash Point N/A

 Use of RETRA


RETRA is a mutant p53-dependent activator of p73 that suppresses mutant p53-bearing cancer cells. RETRA increases the expression level of p73, and a release of p73 from the blocking complex with mutant p53, which produces tumor-suppressor effects[1].

 Names

Name 2-(4,5-dihydro-1,3-thiazol-2-ylsulfanyl)-1-(3,4-dihydroxyphenyl)ethanone,hydrochloride
Synonym More Synonyms

 RETRA Biological Activity

Description RETRA is a mutant p53-dependent activator of p73 that suppresses mutant p53-bearing cancer cells. RETRA increases the expression level of p73, and a release of p73 from the blocking complex with mutant p53, which produces tumor-suppressor effects[1].
Related Catalog
References

[1]. J E Kravchenko, et al. Small-molecule RETRA suppresses mutant p53-bearing cancer cells through a p73-dependent salvage pathway. Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6302-7.  

 Chemical & Physical Properties

Molecular Formula C11H11NO3S2
Molecular Weight 269.34
Exact Mass 304.99500
PSA 120.49000
LogP 2.35410

 Synonyms

RETRA hydrochloride
Reactivation of Transcriptional Reporter Activity
RETRA
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