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RETRA

Names

[ CAS No. ]:
1036069-26-7

[ Name ]:
RETRA

[Synonym ]:
RETRA hydrochloride
Reactivation of Transcriptional Reporter Activity
RETRA

Biological Activity

[Description]:

RETRA is a mutant p53-dependent activator of p73 that suppresses mutant p53-bearing cancer cells. RETRA increases the expression level of p73, and a release of p73 from the blocking complex with mutant p53, which produces tumor-suppressor effects[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Apoptosis >> MDM-2/p53

[References]

[1]. J E Kravchenko, et al. Small-molecule RETRA suppresses mutant p53-bearing cancer cells through a p73-dependent salvage pathway. Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6302-7.  

Chemical & Physical Properties

[ Molecular Formula ]:
C11H11NO3S2

[ Molecular Weight ]:
269.34

[ Exact Mass ]:
304.99500

[ PSA ]:
120.49000

[ LogP ]:
2.35410

Related Compounds