1173023-52-3

1173023-52-3 structure

Name: RETRA hydrochloride
Chemical Name: RETRA
CAS Number: 1173023-52-3
Molecular Formula: C₁₁N₁₁NO₃S_2.HCl
Molecular Weight: 305.801
Create Date: 2020-01-20 18:10:56
Modify Date: 2024-03-02 21:18:15
RETRA hydrochloride is a small molecule mutant p53 reactivator that activates a set of p53-regulated genes and specifically suppresses mutant p53-bearing tumor cells in vitro and in mouse xenograft; increases in the expression level of p73, releases p73 and poduces tumor-suppressor effects similar to the functional reactivation of p53; a p73 activator.

Name	RETRA
Synonyms	Reactivation of Transcriptional Reporter Activity RETRA 2-(4,5-Dihydro-1,3-thiazol-2-ylthio)-1-(3,4-dihydroxyphenyl)ethanone hydrochloride Ethanone, 2-[(4,5-dihydro-2-thiazolyl)thio]-1-(3,4-dihydroxyphenyl)-, hydrochloride (1:1) MFCD11114394 2-(4,5-Dihydro-1,3-thiazol-2-ylsulfanyl)-1-(3,4-dihydroxyphenyl)ethanone hydrochloride (1:1)

Description	RETRA hydrochloride is a small molecule mutant p53 reactivator that activates a set of p53-regulated genes and specifically suppresses mutant p53-bearing tumor cells in vitro and in mouse xenograft; increases in the expression level of p73, releases p73 and poduces tumor-suppressor effects similar to the functional reactivation of p53; a p73 activator.
References	References 1. Kravchenko JE, et al. Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6302-7. 2. Sonnemann J, et al. Eur J Cancer. 2015 May;51(7):841-51. 3. Santag S, et al. Oncogene. 2013 Aug 8;32(32):3676-85. View Related Products by Target MDM2-p53