Levetiracetam

Modify Date: 2024-01-02 12:27:12

Levetiracetam Structure
Levetiracetam structure
 Common Name Levetiracetam
CAS Number 102767-28-2 Molecular Weight 170.209
Density 1.2±0.1 g/cm3 Boiling Point 395.9±25.0 °C at 760 mmHg
Molecular Formula C8H14N2O2 Melting Point 118-119°C
MSDS Chinese USA Flash Point 193.2±23.2 °C
Symbol GHS07
GHS07		 Signal Word Warning

 Use of Levetiracetam


Levetiracetam(UCB L059) is a novel anticonvulsant with antihyperalgesic efficacy in inflammatory pain.Target: Calcium ChannelLevetiracetam is used to control some types of seizures in patients with epilepsy. This medicine cannot cure epilepsy and will only work to control seizures for as long as you continue to use it. The exact mechanism for levetiracetam is unknown. However, the drug binds to a synaptic vesicle protein, SV2A, which is believed to impede nerve conduction across synapses [1].Levetiracetam (10-200 mg/kg), ibuprofen (12.5-100 mg/kg), celecoxib (3.75-30 mg/kg), paracetamol (50-200 mg/kg), caffeine (15-100 mg/kg), and 2-drug combinations of levetiracetam with analgesics/caffeine produced a significant, dose-dependent reduction of inflammatory hyperalgesia. Isobolographic analysis revealed that levetiracetam exerts a synergistic interaction with analgesics, with approximately 7-, 9-, and 11-fold reduction of doses of both drugs in combination of levetiracetam with paracetamol, celecoxib, and ibuprofen, respectively. Analysis of the log dose-response curves for levetiracetam (1-50 mg/kg) in the presence of caffeine (10 mg/kg) and levetiracetam applied alone also revealed a synergistic interaction. Levetiracetam's ED50 in the presence of caffeine was reduced approximately 11-fold [2].Clinical indications: Epilepsy; Social phobiaFDA Approved Date: November 2008Toxicity: depression; hallucinations; suicidal thoughts

 Names

Name levetiracetam
Synonym More Synonyms

 Levetiracetam Biological Activity

Description Levetiracetam(UCB L059) is a novel anticonvulsant with antihyperalgesic efficacy in inflammatory pain.Target: Calcium ChannelLevetiracetam is used to control some types of seizures in patients with epilepsy. This medicine cannot cure epilepsy and will only work to control seizures for as long as you continue to use it. The exact mechanism for levetiracetam is unknown. However, the drug binds to a synaptic vesicle protein, SV2A, which is believed to impede nerve conduction across synapses [1].Levetiracetam (10-200 mg/kg), ibuprofen (12.5-100 mg/kg), celecoxib (3.75-30 mg/kg), paracetamol (50-200 mg/kg), caffeine (15-100 mg/kg), and 2-drug combinations of levetiracetam with analgesics/caffeine produced a significant, dose-dependent reduction of inflammatory hyperalgesia. Isobolographic analysis revealed that levetiracetam exerts a synergistic interaction with analgesics, with approximately 7-, 9-, and 11-fold reduction of doses of both drugs in combination of levetiracetam with paracetamol, celecoxib, and ibuprofen, respectively. Analysis of the log dose-response curves for levetiracetam (1-50 mg/kg) in the presence of caffeine (10 mg/kg) and levetiracetam applied alone also revealed a synergistic interaction. Levetiracetam's ED50 in the presence of caffeine was reduced approximately 11-fold [2].Clinical indications: Epilepsy; Social phobiaFDA Approved Date: November 2008Toxicity: depression; hallucinations; suicidal thoughts
Related Catalog
References

[1]. Meehan AL， et al. A new mechanism for antiepileptic drug action: vesicular entry may mediate the effects of levetiracetam. J Neurophysiol. 2011 Sep;106(3):1227-39.

[2]. Tomi MA, et al. Levetiracetam interacts synergistically with nonsteroidal analgesics and caffeine to produce antihyperalgesia in rats. J Pain. 2013 Nov;14(11):1371-82.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 395.9±25.0 °C at 760 mmHg
Melting Point 118-119°C
Molecular Formula C8H14N2O2
Molecular Weight 170.209
Flash Point 193.2±23.2 °C
Exact Mass 170.105530
PSA 63.40000
LogP -0.67
Vapour Pressure 0.0±0.9 mmHg at 25°C
Index of Refraction 1.519

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H319
Precautionary Statements P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn: Harmful;
Risk Phrases R22
Safety Phrases S26
RIDADR NONH for all modes of transport
RTECS UX9656166
HS Code 2933990090

 Synthetic Route

 Customs

HS Code 2933790090
Summary 2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%

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 Synonyms

(2S)-2-(2-Oxopyrrolidin-1-yl)butanamide
levetiracetamum
2(S)-(2-oxopyrrolidin-1-yl)butyramide
KEPPRA
(2S)-2-(2-Oxo-1-pyrrolidinyl)butanamide
(S)-Etiracetam
Etiracetam levo-isomer
EINECS 200-659-6
ucb L059
(aS)-a-Ethyl-2-oxo-1-pyrrolidineacetamide
1-pyrrolidineacetamide, a-ethyl-2-oxo-, (aS)-
1-Pyrrolidineacetamide, α-ethyl-2-oxo-, (αS)-
(S)-2-(2-Oxopyrrolidin-1-yl)Butanamide
SIB S1
(S)-2-(2-Oxo-1-pyrrolidinyl)butyramide
MFCD03265610
SIB-S1
(-)-(S)-α-Ethyl-2-oxo-1-pyrrolidineacetamide
Keppra XR
Levetiracetam
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Related Compounds: More...
Levetiracetam-d3
1217851-16-5
Levetiracetam-d6
1133229-30-7
Levetiracetam acid
103833-72-3
Levetiracetam impurity 1
1342566-28-2
Levetiracetam impurity B
358629-47-7
Levetiracetam impurity 2
1341459-52-6
LevetiracetaM IMpurity 4
1342229-32-6
LevetiracetaM Impurity 3
1543353-92-9
Levetiracetam impurity 5
1543300-90-8
Chemsrc provides Levetiracetam(CAS#:102767-28-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Levetiracetam are included as well.>> amp version: Levetiracetam

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