Protosappanin B

Modify Date: 2024-01-02 18:49:10

Protosappanin B structure	Common Name	Protosappanin B
	CAS Number	102036-29-3	Molecular Weight	304.29
	Density	1.5±0.1 g/cm3	Boiling Point	655.5±55.0 °C at 760 mmHg
	Molecular Formula	C₁₆H₁₆O₆	Melting Point	N/A
	MSDS	N/A	Flash Point	350.2±31.5 °C

Use of Protosappanin B

Protosappanin B is a phenolic compound extracted from Lignum Sappan. Anti-cancer activity[1]. Protosappanin B induces apoptosis and causes G1 cell cycle arrest in human bladder cancer cells[2].

Name	Protosappanin B
Synonym	More Synonyms

Description	Protosappanin B is a phenolic compound extracted from Lignum Sappan. Anti-cancer activity[1]. Protosappanin B induces apoptosis and causes G1 cell cycle arrest in human bladder cancer cells[2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
Target	Apoptosis[2]
In Vitro	Protosappanin B (12.5, 25, 50, 100, 200 µg/mL, 48 hours) dose-dependently inhibits tumor cells, with IC50s of 21.32 µg/mL, 26.73 µg/mL, and 76.53 µg/mL for SW-480, HCT-116, and BTT cells, respectively[1]. Cell Viability Assay[1] Cell Line: CT-116, SW-480, and BTT Cells Concentration: 12.5, 25, 50, 100, 200 µg/mL Incubation Time: 48 hours Result: Dose-dependently inhibited tumor cells after 48 hours of treatment.
References	[1]. Yang X, et al. Antitumor Effects of Purified Protosappanin B Extracted From Lignum Sappan. Integr Cancer Ther. 2016 Mar;15(1):87-95. [2]. Yang X, et al. Protosappanin B promotes apoptosis and causes G1 cell cycle arrest in human bladder cancer cells. Sci Rep. 2019 Jan 31;9(1):1048.

Density	1.5±0.1 g/cm3
Boiling Point	655.5±55.0 °C at 760 mmHg
Molecular Formula	C₁₆H₁₆O₆
Molecular Weight	304.29
Flash Point	350.2±31.5 °C
Exact Mass	304.094696
PSA	110.38000
LogP	1.13
Vapour Pressure	0.0±2.1 mmHg at 25°C
Index of Refraction	1.700
Storage condition	2~8℃

Hazard Codes	Xi

Protosappanin E1 structure

Protosappanin E1

CAS#:130233-78-2

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(+)-brazilin structure

(+)-brazilin

CAS#:474-07-7

Protosappanin B Structure

Protosappanin B

CAS#:102036-29-3

Literature: Chemical and Pharmaceutical Bulletin, , vol. 38, # 6 p. 1490 - 1494

protosappanin C structure

protosappanin C

CAS#:111534-98-6

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Protosappanin B Structure

Protosappanin B

CAS#:102036-29-3

Literature: Chemical & Pharmaceutical Bulletin, , vol. 35, # 7 p. 3002 - 3005

Precursor 1
CAS#:111534-98-6 protosappanin C
DownStream 0

(7S)-7-(Hydroxymethyl)-7,8-dihydro-6H-dibenzo[b,d]oxocine-3,7,10,11-tetrol

6H-Dibenz[b,d]oxocin-3,7,10,11-tetrol, 7,8-dihydro-7-(hydroxymethyl)-, (7S)-

BioBioPha
China
Product Name: Protosappanin B
Price: ￥Inquiry/20mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Xueping-Zheng

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Protosappanin B
Price: ￥4480.0/5mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Protosappanin B
Price: $280.0/20mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: (7S)-3,7,10,11-Tetrahydroxy-7,8-dihydro-6H-dibenzo[b,d]oxocin-7-methanol
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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