β-CGRP (human)

Modify Date: 2024-01-03 21:14:49

β-CGRP (human) Structure
β-CGRP (human) structure
Common Name β-CGRP (human)
CAS Number 101462-82-2 Molecular Weight 3793.41
Density N/A Boiling Point N/A
Molecular Formula C162H267N51O48S3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of β-CGRP (human)


β-CGRP, human is one of calcitonin peptides, acts via the complex of calcitonin-receptor-like receptor (CRLR) and receptor-activity-modifying protein (RAMP), with IC50s of 1 nM and 300 nM for CRLR/RAMP1 and CRLR/RAMP2 in cells.

 Names

Name β-CGRP, human

 β-CGRP (human) Biological Activity

Description β-CGRP, human is one of calcitonin peptides, acts via the complex of calcitonin-receptor-like receptor (CRLR) and receptor-activity-modifying protein (RAMP), with IC50s of 1 nM and 300 nM for CRLR/RAMP1 and CRLR/RAMP2 in cells.
Related Catalog
Target

IC50: 1 nM (CRLR/RAMP1, cell assay), 300 nM (CRLR/RAMP2, cell assay)[1]

In Vitro β-CGRP, human is one of calcitonin peptides, acts via complex of calcitonin-receptor-like receptor (CRLR) and receptor-activity-modifying protein (RAMP), with IC50s of 1 nM in both SK-N-MC and Swiss 3T3 cells express CRLR and RAMP1, and 130 nM and 300 nM in NG108-15 and HEK293T cells expressing CRLR and RAMP2[1]. CGRP is a potent vasodilator and also shows pro- and -anti-inflammatory activity[2].
References

[1]. McLatchie LM, et al. RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. Nature. 1998 May 28;393(6683):333-9.

[2]. Russell FA, et al. Calcitonin gene-related peptide: physiology and pathophysiology. Physiol Rev. 2014 Oct;94(4):1099-142.

 Chemical & Physical Properties

Molecular Formula C162H267N51O48S3
Molecular Weight 3793.41
Storage condition −20°C

 Safety Information

WGK Germany 3