gadolinium chloride

Modify Date: 2025-08-24 19:00:54

gadolinium chloride Structure
gadolinium chloride structure
 Common Name gadolinium chloride
CAS Number 10138-52-0 Molecular Weight 263.60900
Density 4.52 Boiling Point 1580ºC
Molecular Formula Cl3Gd Melting Point 609ºC
MSDS Chinese USA Flash Point N/A
Symbol GHS07
GHS07		 Signal Word Warning

 Use of gadolinium chloride


Gadolinium chloride is a specific calcium-sensing receptor (CaSR) agonist. Gadolinium chloride can be used for the research of cardiovascular disease[1].

 Names

Name gadolinium trichloride
Synonym More Synonyms

 gadolinium chloride Biological Activity

Description Gadolinium chloride is a specific calcium-sensing receptor (CaSR) agonist. Gadolinium chloride can be used for the research of cardiovascular disease[1].
Related Catalog
Target

CaSR[1]

In Vitro Gadolinium chloride (30 μM; 15 minutes; H9c2 cells) results in increased Bax expression and caspase-3 activation, and decreased Bcl-2 expression in CsA-induced cells[1]. In vitro, GdCl3, a CaSR agonist, has been shown to promote the apoptosis of myocardial cells, which increases ERK1/2 phosphorylation and activates caspase-3[1]. Western Blot Analysis[1] Cell Line: H9c2 cells Concentration: 30 μM Incubation Time: 15 minutes Result: Resulted in increased Bax expression and caspase-3 activation, and decreased Bcl-2 expression in CsA-induced cells.
References

[1]. Li X, et al. Calcium Oxalate Induces Renal Injury through Calcium-Sensing Receptor. Oxid Med Cell Longev. 2016;2016:5203801.

 Chemical & Physical Properties

Density 4.52
Boiling Point 1580ºC
Melting Point 609ºC
Molecular Formula Cl3Gd
Molecular Weight 263.60900
Exact Mass 262.83100
LogP 2.06850
Vapour Pressure 33900mmHg at 25°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
LW4025000
CHEMICAL NAME :
Gadolinium chloride
CAS REGISTRY NUMBER :
10138-52-0
LAST UPDATED :
199701
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
Cl3-Gd
MOLECULAR WEIGHT :
263.60
WISWESSER LINE NOTATION :
GD G3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 17,526,1961
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 17,526,1961 ** ACUTE TOXICITY DATA **
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 17,526,1961
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
378 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal) Lungs, Thorax, or Respiration - other changes
REFERENCE :
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year: 5,437,1962 *** REVIEWS *** TOXICOLOGY REVIEW JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 54,663,1965

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315
Precautionary Statements P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi: Irritant;
Risk Phrases R38
Safety Phrases 36/37
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS ZC0230000

 Synthetic Route

gadolinium(III) chloride hydrate structure

gadolinium(III)...

CAS#:114364-08-8

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gadolinium chloride Structure

gadolinium chloride

CAS#:10138-52-0

Literature: Thermochimica Acta, , vol. 320, # 1-2 p. 1 - 7

 Articles47

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Yttrium oxide/gadolinium oxide-modified platinum nanoparticles as cathodes for the oxygen reduction reaction.

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Ca(2+) -mediated formation of cell polarity is essential for directional migration which plays an important role in physiological and pathological processes in organisms. To examine the critical role ...

 Synonyms

trichlorogadolinium
EINECS 233-386-6
Gadolinium(Iii) Chloride,Ultra Dry,Reo)
Gadolinium(III) chloride
MFCD00011024
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