Desethyl KBT-3022

Modify Date: 2024-01-10 18:32:05

Desethyl KBT-3022 Structure
Desethyl KBT-3022 structure
Common Name Desethyl KBT-3022
CAS Number 101001-72-3 Molecular Weight 420.48100
Density 1.29g/cm3 Boiling Point 630.3ºC at 760mmHg
Molecular Formula C23H20N2O4S Melting Point N/A
MSDS N/A Flash Point 335ºC

 Use of Desethyl KBT-3022


Desethyl KBT-3022 is the main active metabolite of the new antiplatelet agent, KBT-3022.

 Names

Name 2-[2-[4,5-bis(4-methoxyphenyl)-1,3-thiazol-2-yl]pyrrol-1-yl]acetic acid
Synonym More Synonyms

 Desethyl KBT-3022 Biological Activity

Description Desethyl KBT-3022 is the main active metabolite of the new antiplatelet agent, KBT-3022.
Related Catalog
In Vitro Pretreatment with desethyl KBT-3022 0.1, 0.3 and 1 mg/kg, i.v. prolongs the time required to achieve thrombotic occlusion in the femoral artery and inhibits collagen-induced platelet aggregation in whole blood ex vivo, each in a dose-dependent manner. Desethyl KBT-3022 inhibits the thrombin-induced aggregation of washed platelets in a concentration-dependent manner 1–40 μM[1].
References

[1]. Shimazawa M, et al. Antithrombotic effects in a rat model of aspirin-insensitive arterial thrombosis of desethyl KBT-3022, the main active metabolite of a new antiplatelet agent, KBT-3022. Eur J Pharmacol. 1997 Jun 11;328(2-3):183-9.

 Chemical & Physical Properties

Density 1.29g/cm3
Boiling Point 630.3ºC at 760mmHg
Molecular Formula C23H20N2O4S
Molecular Weight 420.48100
Flash Point 335ºC
Exact Mass 420.11400
PSA 101.82000
LogP 5.04740
Vapour Pressure 9.4E-17mmHg at 25°C
Index of Refraction 1.642

 Synonyms

1H-Pyrrole-1-aceticacid,2-[4,5-bis(4-methoxyphenyl)-2-thiazolyl]
Desethyl KB 3022
2-(4,5-Bis(4-methoxylphenyl)thiazol-2-yl)pyrrol-1-ylacetic acid
Desethyl kbt-3022