101001-72-3

101001-72-3 structure

Name: Desethyl KBT-3022
Chemical Name: 2-[2-[4,5-bis(4-methoxyphenyl)-1,3-thiazol-2-yl]pyrrol-1-yl]acetic acid
CAS Number: 101001-72-3
Molecular Formula: C₂₃H₂₀N₂O₄S
Molecular Weight: 420.48100
Catalog: Signaling Pathways Metabolic Enzyme/Protease Thrombin
Create Date: 2017-10-20 20:22:16
Modify Date: 2024-01-10 18:32:05
Desethyl KBT-3022 is the main active metabolite of the new antiplatelet agent, KBT-3022.

Name	2-[2-[4,5-bis(4-methoxyphenyl)-1,3-thiazol-2-yl]pyrrol-1-yl]acetic acid
Synonyms	1H-Pyrrole-1-aceticacid,2-[4,5-bis(4-methoxyphenyl)-2-thiazolyl] Desethyl KB 3022 2-(4,5-Bis(4-methoxylphenyl)thiazol-2-yl)pyrrol-1-ylacetic acid Desethyl kbt-3022

Description	Desethyl KBT-3022 is the main active metabolite of the new antiplatelet agent, KBT-3022.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Thrombin Research Areas >> Cardiovascular Disease
In Vitro	Pretreatment with desethyl KBT-3022 0.1, 0.3 and 1 mg/kg, i.v. prolongs the time required to achieve thrombotic occlusion in the femoral artery and inhibits collagen-induced platelet aggregation in whole blood ex vivo, each in a dose-dependent manner. Desethyl KBT-3022 inhibits the thrombin-induced aggregation of washed platelets in a concentration-dependent manner 1–40 μM[1].
References	[1]. Shimazawa M, et al. Antithrombotic effects in a rat model of aspirin-insensitive arterial thrombosis of desethyl KBT-3022, the main active metabolite of a new antiplatelet agent, KBT-3022. Eur J Pharmacol. 1997 Jun 11;328(2-3):183-9.