KB3022

Modify Date: 2024-01-11 18:26:57

KB3022 Structure
KB3022 structure
Common Name KB3022
CAS Number 101001-34-7 Molecular Weight 448.53400
Density 1.22g/cm3 Boiling Point 600.3ºC at 760mmHg
Molecular Formula C25H24N2O4S Melting Point N/A
MSDS N/A Flash Point 316.8ºC

 Use of KB3022


KB3022 is a cyclooxygenase (COX) inhibitor.

 Names

Name ethyl 2-[2-[4,5-bis(4-methoxyphenyl)-1,3-thiazol-2-yl]pyrrol-1-yl]acetate
Synonym More Synonyms

 KB3022 Biological Activity

Description KB3022 is a cyclooxygenase (COX) inhibitor.
Related Catalog
Target

Cyclooxygenase

In Vitro KB3022 (Pamicogrel) is a cyclooxygenase inhibitor with platelet anti-aggregatory properties which is under development by Kanebo for chronic arterial occlusion. KB3022 also has potential in both prophylaxis and treatment of ischemic brain injury[1].
References

[1]. Light P. Pamicogrel (Kanebo). IDrugs. 1999 Sep;2(9):938-42.

 Chemical & Physical Properties

Density 1.22g/cm3
Boiling Point 600.3ºC at 760mmHg
Molecular Formula C25H24N2O4S
Molecular Weight 448.53400
Flash Point 316.8ºC
Exact Mass 448.14600
PSA 90.82000
LogP 5.52590
Vapour Pressure 2.28E-14mmHg at 25°C
Index of Refraction 1.612

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UX9276399
CHEMICAL NAME :
1H-Pyrrole-1-acetic acid, 2-(4,5-bis(4-methoxyphenyl)-2-thiazolyl)-, ethyl ester
CAS REGISTRY NUMBER :
101001-34-7
LAST UPDATED :
199606
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C25-H24-N2-O4-S
MOLECULAR WEIGHT :
448.57

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4659726

 Synonyms

KB-3022
Ethyl 2-(4,5-bis(4-methoxyphenyl)-2-thiazolyl)-1H-pyrrole-1-acetate
Pamicogrel
KBT-3022
1H-Pyrrole-1-acetic acid,2-(4,5-bis(4-methoxyphenyl)-2-thiazolyl)-,ethyl ester
Ethyl 2-(4,5-bis(p-methoxyphenyl)-2-thiazolyl)pyrrole-1-acetate
ethyl 2-[4,5-bis(4-methoxyphenyl)thiazol-2-yl]-pyrrole-1-acetate
ethyl 2-<4,5-bis(4-methoxyphenyl)thiazole-2-yl>pyrrol-1-yl acetate
KB3022
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