KB3022

Names

[ Name ]:
KB3022

[Synonym ]:
KB-3022
Ethyl 2-(4,5-bis(4-methoxyphenyl)-2-thiazolyl)-1H-pyrrole-1-acetate
Pamicogrel
KBT-3022
1H-Pyrrole-1-acetic acid,2-(4,5-bis(4-methoxyphenyl)-2-thiazolyl)-,ethyl ester
Ethyl 2-(4,5-bis(p-methoxyphenyl)-2-thiazolyl)pyrrole-1-acetate
ethyl 2-[4,5-bis(4-methoxyphenyl)thiazol-2-yl]-pyrrole-1-acetate
ethyl 2-<4,5-bis(4-methoxyphenyl)thiazole-2-yl>pyrrol-1-yl acetate
KB3022

Biological Activity

[Description]:

KB3022 is a cyclooxygenase (COX) inhibitor.

[Related Catalog]:

Research Areas >> Cardiovascular Disease

[Target]

Cyclooxygenase

[In Vitro]

KB3022 (Pamicogrel) is a cyclooxygenase inhibitor with platelet anti-aggregatory properties which is under development by Kanebo for chronic arterial occlusion. KB3022 also has potential in both prophylaxis and treatment of ischemic brain injury[1].

[References]

[1]. Light P. Pamicogrel (Kanebo). IDrugs. 1999 Sep;2(9):938-42.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.22g/cm3

[ Boiling Point ]:
600.3ºC at 760mmHg

[ Molecular Formula ]:
C₂₅H₂₄N₂O₄S

[ Molecular Weight ]:
448.53400

[ Flash Point ]:
316.8ºC

[ Exact Mass ]:
448.14600

[ PSA ]:
90.82000

[ LogP ]:
5.52590

[ Vapour Pressure ]:
2.28E-14mmHg at 25°C

[ Index of Refraction ]:
1.612

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UX9276399

CHEMICAL NAME :: 1H-Pyrrole-1-acetic acid, 2-(4,5-bis(4-methoxyphenyl)-2-thiazolyl)-, ethyl ester

CAS REGISTRY NUMBER :: 101001-34-7

LAST UPDATED :: 199606

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C25-H24-N2-O4-S

MOLECULAR WEIGHT :: 448.57

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4659726