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Product Name: Pamicogrel
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101001-34-7

101001-34-7 structure

101001-34-7 structure

Name: KB3022
Chemical Name: ethyl 2-[2-[4,5-bis(4-methoxyphenyl)-1,3-thiazol-2-yl]pyrrol-1-yl]acetate
CAS Number: 101001-34-7
Molecular Formula: C₂₅H₂₄N₂O₄S
Molecular Weight: 448.53400
Catalog: Research Areas Cardiovascular Disease
Create Date: 2017-12-27 18:59:52
Modify Date: 2024-01-11 18:26:57
KB3022 is a cyclooxygenase (COX) inhibitor.

Name	ethyl 2-[2-[4,5-bis(4-methoxyphenyl)-1,3-thiazol-2-yl]pyrrol-1-yl]acetate
Synonyms	KB-3022 Ethyl 2-(4,5-bis(4-methoxyphenyl)-2-thiazolyl)-1H-pyrrole-1-acetate Pamicogrel KBT-3022 1H-Pyrrole-1-acetic acid,2-(4,5-bis(4-methoxyphenyl)-2-thiazolyl)-,ethyl ester Ethyl 2-(4,5-bis(p-methoxyphenyl)-2-thiazolyl)pyrrole-1-acetate ethyl 2-[4,5-bis(4-methoxyphenyl)thiazol-2-yl]-pyrrole-1-acetate ethyl 2-<4,5-bis(4-methoxyphenyl)thiazole-2-yl>pyrrol-1-yl acetate KB3022

Description	KB3022 is a cyclooxygenase (COX) inhibitor.
Related Catalog	Research Areas >> Cardiovascular Disease
Target	Cyclooxygenase
In Vitro	KB3022 (Pamicogrel) is a cyclooxygenase inhibitor with platelet anti-aggregatory properties which is under development by Kanebo for chronic arterial occlusion. KB3022 also has potential in both prophylaxis and treatment of ischemic brain injury[1].
References	[1]. Light P. Pamicogrel (Kanebo). IDrugs. 1999 Sep;2(9):938-42.

Density	1.22g/cm3
Boiling Point	600.3ºC at 760mmHg
Molecular Formula	C₂₅H₂₄N₂O₄S
Molecular Weight	448.53400
Flash Point	316.8ºC
Exact Mass	448.14600
PSA	90.82000
LogP	5.52590
Vapour Pressure	2.28E-14mmHg at 25°C
Index of Refraction	1.612

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UX9276399

CHEMICAL NAME :: 1H-Pyrrole-1-acetic acid, 2-(4,5-bis(4-methoxyphenyl)-2-thiazolyl)-, ethyl ester

CAS REGISTRY NUMBER :: 101001-34-7

LAST UPDATED :: 199606

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C25-H24-N2-O4-S

MOLECULAR WEIGHT :: 448.57

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4659726