Gastrin I (human)
Modify Date: 2025-08-25 14:40:24
Gastrin I (human) structure
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Common Name | Gastrin I (human) | ||
|---|---|---|---|---|
| CAS Number | 10047-33-3 | Molecular Weight | 2098.203 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 2401.4±65.0 °C at 760 mmHg | |
| Molecular Formula | C97H124N20O31S | Melting Point | N/A | |
| MSDS | USA | Flash Point | 1406.1±34.3 °C | |
Use of Gastrin I (human)Gastrin-1, human is the endogenous peptide produced in the stomach, and increases gastric acid secretion via cholecystokinin 2 (CCK2) receptor. |
| Name | 5-Oxo-L-prolylglycyl-L-prolyl-L-tryptophyl-L-leucyl-L-α-glutamyl-L-α-glutamyl-L-α-glutamyl-L-α-glutamyl-L-α-glutamyl-L-alanyl-L-tyrosylglycyl-L-tryptophyl-L-methionyl-L-α-aspartyl-L-phenylalaninamide |
|---|---|
| Synonym | More Synonyms |
| Description | Gastrin-1, human is the endogenous peptide produced in the stomach, and increases gastric acid secretion via cholecystokinin 2 (CCK2) receptor. |
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| Related Catalog | |
| Target |
CCK2 receptor[1] |
| In Vitro | Gastrin-1, human is the endogenous peptide produced in the stomach, and acts via cholecystokinin 2 (CCK2) receptor[1]. |
| In Vivo | Gastrin-1 (1.5, 5, 15 and 45 nmol/kg, i.v.) increases pepsinogen and acid secretion in rats[1]. |
| Animal Admin | Rats[1] The first set of experiments is carried out on rats with intact vagus nerves which are acutely treated with CCK-8S or Gastrin-1 at the doses of 1.5, 5, 15 and 45 nmol/kg. Both these peptides are administered i.v. as a bolus immediately after the collection of basal effluent samples. In experiments investigating the involvement of muscarinic, histamine H or CCK receptors in the gastric 2 secretory responses elicited by CCK-8S or Gastrin-1, the animals are pretreated with atropine 1 μmol/kg i.v., cimetidine 10 μmolrkg i.v., devazepide 1.25-2.5 μmol/kg i.v. or L-365,260 2.5-5 μmol/kg i.v., 10 min before ending the collection of the second basal effluent sample. Additional experiments are performed in animals pretreated with the irreversible inhibitor of histidine decarboxylase, α-fluoromethylhistidine (450 mmol/kg i.p. twice daily for two consecutive days), in order to suppress endogenous histamine production from digestive enterochromaffin-like cells[1]. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 2401.4±65.0 °C at 760 mmHg |
| Molecular Formula | C97H124N20O31S |
| Molecular Weight | 2098.203 |
| Flash Point | 1406.1±34.3 °C |
| Exact Mass | 2096.846191 |
| PSA | 829.91000 |
| LogP | -1.10 |
| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
| Index of Refraction | 1.624 |
| Storage condition | −20°C |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xn |
| Safety Phrases | S22-S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
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In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration.
Nature 494 , 247-50, (2013) The Wnt target gene Lgr5 (leucine-rich-repeat-containing G-protein-coupled receptor 5) marks actively dividing stem cells in Wnt-driven, self-renewing tissues such as small intestine and colon, stomac... |
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Human gastrin: a Helicobacter pylori--specific growth factor.
Gastroenterology 117 , 1113-1118, (1999) Helicobacter pylori resides within the gastric mucosa, a niche hostile to other microorganisms. Human gastrin levels are elevated after infection and return to normal after eradication. The aim of thi... |
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Evidence for a functional role of the cholecystokinin-B/gastrin receptor in the human fetal and adult pancreas.
Diabetes 48 , 2015-2021, (1999) Gastrin (G) and cholecystokinin (CCK) are gastrointestinal neuropeptides that are released into circulation during a meal. G is also transiently expressed during embryogenic and early ontogenic develo... |
| 5-Oxo-L-prolylglycyl-L-prolyl-L-tryptophyl-L-leucyl-L-α-glutamyl-L-α-glutamyl-L-α-glutamyl-L-α-glutamyl-L-α-glutamyl-L-alanyl-L-tyrosylglycyl-L-tryptophyl-L-methionyl-L-α-aspartyl-L-phenylalaninamide |
| EINECS 233-157-0 |
| L-Phenylalaninamide, 5-oxo-L-prolylglycyl-L-prolyl-L-tryptophyl-L-leucyl-L-α-glutamyl-L-α-glutamyl-L-α-glutamyl-L-α-glutamyl-L-α-glutamyl-L-alanyl-L-tyrosylglycyl-L-tryptophyl-L-methionyl-L-α-aspartyl- |
| pyroGlu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2 |
| L-Phenylalaninamide, 5-oxo-L-prolylglycyl-L-prolyl-L-tryptophyl-L-leucyl-L-α-glutamyl-L-α-glutamyl-L-α-glutamyl-L-α-glutamyl-L-α-glutamyl-L-alanyl-L-tyrosylglycyl-L-tryptophyl-L-me thionyl-L-α-aspartyl- |
| MFCD00076500 |
| 5-Oxo-L-prolylglycyl-L-prolyl-L-tryptophyl-L-leucyl-L-α-glutamyl-L-α-glutamyl-L-α-glutamyl-L-α-glutamyl-L-α-glutamyl-L-alanyl-L-tyrosylglycyl-L-tryptophyl-L-methionyl-L-α-aspar tyl-L-phenylalaninamide |
| Gastrin I Human |
| GLP-GLY-PRO-TRP-LEU-GLU-GLU-GLU-GLU-GLU-ALA-TYR-GLY-TRP-MET-ASP-PHE-NH2: GLP-GPWLEEEEEAYGWMDF-NH2 |
| Pyr-GPWLEEEEEAYGWMDF-NH2 |
| Gastrin-1, human |
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- Shanghai Nianxing Industrial Co., Ltd
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- Product Name: Gastrin I (human)
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- Purity: 98.0%
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- GL Biochem (Shanghai) Ltd.
- China
- Product Name: Gastrin-1, human
- Price: ￥Inquiry/1kg
- Purity: 98.0%
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- Zhongshan Xingrui Chemical Co. , Ltd.
- China
- Product Name: Gastrin I (human)
- Price: ￥Inquiry/25kg
- Purity: 99.0%
- Delivery: Inquiry
- Contact: Wang Jie
- Email: 3096638339@qq.com
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