Picrasidine I

Modify Date: 2025-08-25 17:38:44

Picrasidine I structure	Common Name	Picrasidine I
	CAS Number	100234-59-1	Molecular Weight	240.257
	Density	1.4±0.1 g/cm3	Boiling Point	528.2±45.0 °C at 760 mmHg
	Molecular Formula	C₁₄H₁₂N₂O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	273.3±28.7 °C

Use of Picrasidine I

Picrasidine I is an anti-inflammatory and anti-osteoclastogenic dimeric alkaloid that can be isolated from Picrasma quassioides. Picrasidine I inducs cell cycle arrest, and triggers cell Apoptosis by downregulats ERK and Akt pathways. Picrasidine I inhibits the activation of MAPKs, NF-κB and ROS generation, and suppresses the expression of c-Fos and NFATc1[1][2].

Name	4-Methoxy-1-vinyl-9H-β-carbolin-8-ol
Synonym	More Synonyms

Description	Picrasidine I is an anti-inflammatory and anti-osteoclastogenic dimeric alkaloid that can be isolated from Picrasma quassioides. Picrasidine I inducs cell cycle arrest, and triggers cell Apoptosis by downregulats ERK and Akt pathways. Picrasidine I inhibits the activation of MAPKs, NF-κB and ROS generation, and suppresses the expression of c-Fos and NFATc1[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Inflammation/Immunology
References	[1]. Ho HY, et al. Picrasidine I Triggers Heme Oxygenase-1-Induced Apoptosis in Nasopharyngeal Carcinoma Cells via ERK and Akt Signaling Pathways. Int J Mol Sci. 2022 May 29;23(11):6103. [2]. Kong L, et al. Picrasidine I from Picrasma Quassioides Suppresses Osteoclastogenesis via Inhibition of RANKL Induced Signaling Pathways and Attenuation of ROS Production. Cell Physiol Biochem. 2017;43(4):1425-1435.

Description

Related Catalog

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Inflammation/Immunology

References

[1]. Ho HY, et al. Picrasidine I Triggers Heme Oxygenase-1-Induced Apoptosis in Nasopharyngeal Carcinoma Cells via ERK and Akt Signaling Pathways. Int J Mol Sci. 2022 May 29;23(11):6103.

[2]. Kong L, et al. Picrasidine I from Picrasma Quassioides Suppresses Osteoclastogenesis via Inhibition of RANKL Induced Signaling Pathways and Attenuation of ROS Production. Cell Physiol Biochem. 2017;43(4):1425-1435.

Density	1.4±0.1 g/cm3
Boiling Point	528.2±45.0 °C at 760 mmHg
Molecular Formula	C₁₄H₁₂N₂O₂
Molecular Weight	240.257
Flash Point	273.3±28.7 °C
Exact Mass	240.089874
PSA	58.14000
LogP	3.05
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.772

Hazard Codes	Xi

4-Methoxy-8-tos...

CAS#:245662-13-9

~78%

Picrasidine I

CAS#:100234-59-1

Literature: Suzuki, Hideharu; Unemoto, Minoru; Hagiwara, Mayumi; Ohyama, Takako; Yokoyama, Yuusaku; Murakami, Yasuoki Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 12 p. 1717 - 1723

Ethyl 7-tosylox...

CAS#:126260-57-9

Picrasidine I

CAS#:100234-59-1

4-Methoxy-8-tos...

CAS#:245662-09-3

Picrasidine I

CAS#:100234-59-1

Ethyl [(7-tosyl...

CAS#:245662-03-7

Picrasidine I

CAS#:100234-59-1

Methyl 4-methox...

CAS#:245662-11-7

Picrasidine I

CAS#:100234-59-1

Precursor 4
CAS#:245662-13-9 4-Methoxy-8-tos... CAS#:245662-09-3 4-Methoxy-8-tos... CAS#:245662-03-7 Ethyl [(7-tosyl... CAS#:245662-11-7 Methyl 4-methox...
DownStream 1
CAS#:65236-62-6 4,8-Dimethoxy-1...

4-Methoxy-1-vinyl-9H-Beta-carbolin-8-ol

Picrasidine I

4-ethyl-quinolin-8-ol

8-Quinolinol,4-ethyl

9H-Pyrido[3,4-b]indol-8-ol, 1-ethenyl-4-methoxy-

8-Hydroxy-4-ethyl-chinolin

4-Methoxy-1-vinyl-9H-β-carbolin-8-ol

8-hydroxydehydrocrenatine

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Picrasidine I

Use of Picrasidine I

Names

Picrasidine I Biological Activity

Chemical & Physical Properties

Safety Information

Synthetic Route

Precursor & DownStream

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.