100234-59-1

100234-59-1 structure

Name: Picrasidine I
Chemical Name: 4-Methoxy-1-vinyl-9H-β-carbolin-8-ol
CAS Number: 100234-59-1
Molecular Formula: C₁₄H₁₂N₂O₂
Molecular Weight: 240.257
Catalog: Natural product Alkaloid
Create Date: 2017-03-28 22:51:10
Modify Date: 2024-01-05 13:08:05
Picrasidine I is an anti-inflammatory and anti-osteoclastogenic dimeric alkaloid that can be isolated from Picrasma quassioides. Picrasidine I inducs cell cycle arrest, and triggers cell Apoptosis by downregulats ERK and Akt pathways. Picrasidine I inhibits the activation of MAPKs, NF-κB and ROS generation, and suppresses the expression of c-Fos and NFATc1[1][2].

Name	4-Methoxy-1-vinyl-9H-β-carbolin-8-ol
Synonyms	4-Methoxy-1-vinyl-9H-Beta-carbolin-8-ol Picrasidine I 4-ethyl-quinolin-8-ol 8-Quinolinol,4-ethyl 9H-Pyrido[3,4-b]indol-8-ol, 1-ethenyl-4-methoxy- 8-Hydroxy-4-ethyl-chinolin 4-Methoxy-1-vinyl-9H-β-carbolin-8-ol 8-hydroxydehydrocrenatine

Description	Picrasidine I is an anti-inflammatory and anti-osteoclastogenic dimeric alkaloid that can be isolated from Picrasma quassioides. Picrasidine I inducs cell cycle arrest, and triggers cell Apoptosis by downregulats ERK and Akt pathways. Picrasidine I inhibits the activation of MAPKs, NF-κB and ROS generation, and suppresses the expression of c-Fos and NFATc1[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Inflammation/Immunology
References	[1]. Ho HY, et al. Picrasidine I Triggers Heme Oxygenase-1-Induced Apoptosis in Nasopharyngeal Carcinoma Cells via ERK and Akt Signaling Pathways. Int J Mol Sci. 2022 May 29;23(11):6103. [2]. Kong L, et al. Picrasidine I from Picrasma Quassioides Suppresses Osteoclastogenesis via Inhibition of RANKL Induced Signaling Pathways and Attenuation of ROS Production. Cell Physiol Biochem. 2017;43(4):1425-1435.