Picrasidine I

Names

[ Name ]:
Picrasidine I

[Synonym ]:
4-Methoxy-1-vinyl-9H-Beta-carbolin-8-ol
Picrasidine I
4-ethyl-quinolin-8-ol
8-Quinolinol,4-ethyl
9H-Pyrido[3,4-b]indol-8-ol, 1-ethenyl-4-methoxy-
8-Hydroxy-4-ethyl-chinolin
4-Methoxy-1-vinyl-9H-β-carbolin-8-ol
8-hydroxydehydrocrenatine

Biological Activity

[Description]:

Picrasidine I is an anti-inflammatory and anti-osteoclastogenic dimeric alkaloid that can be isolated from Picrasma quassioides. Picrasidine I inducs cell cycle arrest, and triggers cell Apoptosis by downregulats ERK and Akt pathways. Picrasidine I inhibits the activation of MAPKs, NF-κB and ROS generation, and suppresses the expression of c-Fos and NFATc1[1][2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Inflammation/Immunology

[References]

[1]. Ho HY, et al. Picrasidine I Triggers Heme Oxygenase-1-Induced Apoptosis in Nasopharyngeal Carcinoma Cells via ERK and Akt Signaling Pathways. Int J Mol Sci. 2022 May 29;23(11):6103.

[2]. Kong L, et al. Picrasidine I from Picrasma Quassioides Suppresses Osteoclastogenesis via Inhibition of RANKL Induced Signaling Pathways and Attenuation of ROS Production. Cell Physiol Biochem. 2017;43(4):1425-1435.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
528.2±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₄H₁₂N₂O₂

[ Molecular Weight ]:
240.257

[ Flash Point ]:
273.3±28.7 °C

[ Exact Mass ]:
240.089874

[ PSA ]:
58.14000

[ LogP ]:
3.05

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.772

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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