GSK-1482160

Modify Date: 2024-04-04 18:29:29

GSK-1482160 Structure
GSK-1482160 structure
Common Name GSK-1482160
CAS Number 1001389-72-5 Molecular Weight 334.72100
Density N/A Boiling Point N/A
Molecular Formula C14H14ClF3N2O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of GSK-1482160


GSK-1482160 is an orally available negative allosteric modulator of the P2X7 receptor. P2X7 receptors are involved in the production of pro-inflammatory cytokines, such as Il-1β, by central and peripheral immune cells. GSK-1482160 has the potential for the research of inflammation diseases[1].

 Names

Name N-{[2-chloro-3-(trifluoromethyl)phenyl]methyl}-1-methyl-5-oxo-L-prolinamide

 GSK-1482160 Biological Activity

Description GSK-1482160 is an orally available negative allosteric modulator of the P2X7 receptor. P2X7 receptors are involved in the production of pro-inflammatory cytokines, such as Il-1β, by central and peripheral immune cells. GSK-1482160 has the potential for the research of inflammation diseases[1].
Related Catalog
References

[1]. Ali Z, et al. Pharmacokinetic and pharmacodynamic profiling of a P2X7 receptor allosteric modulator GSK1482160 in healthy human subjects. Br J Clin Pharmacol. 2013;75(1):197-207. doi:10.1111/j.1365-2125.2012.04320.x

 Chemical & Physical Properties

Molecular Formula C14H14ClF3N2O2
Molecular Weight 334.72100
Exact Mass 334.07000
PSA 49.41000
LogP 2.92460
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