143313-51-3

143313-51-3 structure

Name: Ac-Tyr-Val-Ala-Asp-aldehyde (pseudo acid)
Chemical Name: ac-yvad-cho
CAS Number: 143313-51-3
Molecular Formula: C₂₃H₃₂N₄O₈
Molecular Weight: 492.522
Catalog: Biochemical Peptide
Create Date: 2018-12-28 06:29:31
Modify Date: 2024-01-04 14:58:49
Ac-YVAD-CHO (L-709049) is a potent, reversible, specific tetrapeptide interleukin-lβ converting enzyme (ICE) inhibitor with mouse and human Ki values of 3.0 and 0.76 nM. Ac-YVAD-CHO can suppress the production of mature IL-lβ[1].

Name	ac-yvad-cho
Synonyms	pase inhibitor i acetyl-yvad-aldehyde ice inhibitor ac-yvad-aldehyde N-Acetyl-L-tyrosyl-L-valyl-N-[(2S)-1-carboxy-3-oxopropan-2-yl]-L-alaninamide L-Alaninamide, N-acetyl-L-tyrosyl-L-valyl-N-((1S)-2-carboxy-1-formylethyl)- tyr-val-ala-asp-cho N-Acetyl-L-tyrosyl-L-valyl-N-[(2S)-1-carboxy-3-oxo-2-propanyl]-L-alaninamide yvad-cho L-Alaninamide, N-acetyl-L-tyrosyl-L-valyl-N-[(1S)-2-carboxy-1-formylethyl]- ice inhibitor i

Description	Ac-YVAD-CHO (L-709049) is a potent, reversible, specific tetrapeptide interleukin-lβ converting enzyme (ICE) inhibitor with mouse and human Ki values of 3.0 and 0.76 nM. Ac-YVAD-CHO can suppress the production of mature IL-lβ[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Interleukin Related Research Areas >> Inflammation/Immunology
Target	IL-1β:3 nM (Ki) IL-1β:0.76 nM (Ki)
In Vitro	Ac-YVAD-CHO inhibits IL-1β in a dose-dependent manner, with mouse and human IC50 values of 2.5 and 0.7 μM. Ac-YVAD-CHO (0.01~100 μM) reduces the elevations of IL-lβ in the plasma and peritoneal fluid treated with LPS in a dose-related manner[1].
In Vivo	Ac-YVAD-CHO (10 mg/kg; i.p.; 1 hour) is absorbed from the peritoneal cavity, as well as cleared from the blood rapidly[1]. Ac-YVAD-CHO (50 mg/kg; i.p.; 1 hour) drops precipitously to approximately 1 and 0.2 μM at 30 and 60 minutes after injection[1]. Ac-YVAD-CHO (30 mg/kg; i.p.; 6 hours) suppresses IL-1β levels[1]. Animal Model: CD1 female mice Dosage: 10 mg/kg (Pharmacokinetic Analysis) Administration: I.p.; 1 hour Result: Absorbed from the peritoneal cavity, as well as cleared from the blood rapidly. Animal Model: CD1 female mice Dosage: 50 mg/kg (Pharmacokinetic Analysis) Administration: I.p.; 1 hour Result: Dropped precipitously to approximately 1 and 0.2 μM at 30 and 60 minutes after injection. Animal Model: P. acnes-sensitized mice Dosage: 30 mg/kg Administration: I.p.; 6 hours Result: Suppressed IL-1β levels.
References	[1]. Fletcher DS, et al. A synthetic inhibitor of interleukin-1 beta converting enzyme prevents endotoxin-induced interleukin-1 beta production in vitro and in vivo. J Interferon Cytokine Res. 1995;15(3):243-248.

Density	1.3±0.1 g/cm3
Boiling Point	937.7±65.0 °C at 760 mmHg
Molecular Formula	C₂₃H₃₂N₄O₈
Molecular Weight	492.522
Flash Point	520.9±34.3 °C
Exact Mass	492.222015
PSA	191.00000
LogP	0.79
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.552
Storage condition	−20°C

WGK Germany	3

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