Ac-Tyr-Val-Ala-Asp-aldehyde (pseudo acid)

Modify Date: 2025-08-22 20:13:00

Ac-Tyr-Val-Ala-Asp-aldehyde (pseudo acid) structure	Common Name	Ac-Tyr-Val-Ala-Asp-aldehyde (pseudo acid)
	CAS Number	143313-51-3	Molecular Weight	492.522
	Density	1.3±0.1 g/cm3	Boiling Point	937.7±65.0 °C at 760 mmHg
	Molecular Formula	C₂₃H₃₂N₄O₈	Melting Point	N/A
	MSDS	N/A	Flash Point	520.9±34.3 °C

Use of Ac-Tyr-Val-Ala-Asp-aldehyde (pseudo acid)

Ac-YVAD-CHO (L-709049) is a potent, reversible, specific tetrapeptide interleukin-lβ converting enzyme (ICE) inhibitor with mouse and human Ki values of 3.0 and 0.76 nM. Ac-YVAD-CHO can suppress the production of mature IL-lβ[1].

Name	ac-yvad-cho
Synonym	More Synonyms

Description	Ac-YVAD-CHO (L-709049) is a potent, reversible, specific tetrapeptide interleukin-lβ converting enzyme (ICE) inhibitor with mouse and human Ki values of 3.0 and 0.76 nM. Ac-YVAD-CHO can suppress the production of mature IL-lβ[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Interleukin Related Research Areas >> Inflammation/Immunology
Target	IL-1β:3 nM (Ki) IL-1β:0.76 nM (Ki)
In Vitro	Ac-YVAD-CHO inhibits IL-1β in a dose-dependent manner, with mouse and human IC50 values of 2.5 and 0.7 μM. Ac-YVAD-CHO (0.01~100 μM) reduces the elevations of IL-lβ in the plasma and peritoneal fluid treated with LPS in a dose-related manner[1].
In Vivo	Ac-YVAD-CHO (10 mg/kg; i.p.; 1 hour) is absorbed from the peritoneal cavity, as well as cleared from the blood rapidly[1]. Ac-YVAD-CHO (50 mg/kg; i.p.; 1 hour) drops precipitously to approximately 1 and 0.2 μM at 30 and 60 minutes after injection[1]. Ac-YVAD-CHO (30 mg/kg; i.p.; 6 hours) suppresses IL-1β levels[1]. Animal Model: CD1 female mice Dosage: 10 mg/kg (Pharmacokinetic Analysis) Administration: I.p.; 1 hour Result: Absorbed from the peritoneal cavity, as well as cleared from the blood rapidly. Animal Model: CD1 female mice Dosage: 50 mg/kg (Pharmacokinetic Analysis) Administration: I.p.; 1 hour Result: Dropped precipitously to approximately 1 and 0.2 μM at 30 and 60 minutes after injection. Animal Model: P. acnes-sensitized mice Dosage: 30 mg/kg Administration: I.p.; 6 hours Result: Suppressed IL-1β levels.
References	[1]. Fletcher DS, et al. A synthetic inhibitor of interleukin-1 beta converting enzyme prevents endotoxin-induced interleukin-1 beta production in vitro and in vivo. J Interferon Cytokine Res. 1995;15(3):243-248.

Density	1.3±0.1 g/cm3
Boiling Point	937.7±65.0 °C at 760 mmHg
Molecular Formula	C₂₃H₃₂N₄O₈
Molecular Weight	492.522
Flash Point	520.9±34.3 °C
Exact Mass	492.222015
PSA	191.00000
LogP	0.79
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.552
Storage condition	−20°C

WGK Germany	3

pase inhibitor i

acetyl-yvad-aldehyde

ice inhibitor

ac-yvad-aldehyde

N-Acetyl-L-tyrosyl-L-valyl-N-[(2S)-1-carboxy-3-oxopropan-2-yl]-L-alaninamide

L-Alaninamide, N-acetyl-L-tyrosyl-L-valyl-N-((1S)-2-carboxy-1-formylethyl)-

tyr-val-ala-asp-cho

N-Acetyl-L-tyrosyl-L-valyl-N-[(2S)-1-carboxy-3-oxo-2-propanyl]-L-alaninamide

yvad-cho

L-Alaninamide, N-acetyl-L-tyrosyl-L-valyl-N-[(1S)-2-carboxy-1-formylethyl]-

ice inhibitor i

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Ac-YVAD-CHO
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: L 709049
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: L 709049
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

Nanjing Peptide Biotech Ltd
China
Product Name: Acetyl-tyrosyl-valyl-alanyl-aspartal
Price: ￥Inquiry/10g ￥Inquiry/100g ￥Inquiry/1kg ￥Inquiry/10kg
Purity: 98.0%
Delivery: 7 Day
Contact: jom
Email: chenglong.fan@njpeptide.com

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Use of Ac-Tyr-Val-Ala-Asp-aldehyde (pseudo acid)

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.