23971-42-8

23971-42-8 structure

Name: Meranzin
Chemical Name: 8-{[(2S)-3,3-Dimethyl-2-oxiranyl]methyl}-7-methoxy-2H-chromen-2-o ne
CAS Number: 23971-42-8
Molecular Formula: C₁₅H₁₆O₄
Molecular Weight: 260.285
Catalog: Natural product Coumarin
Create Date: 2017-07-12 01:50:47
Modify Date: 2024-01-03 12:04:26
Meranzin is an absorbed bioactive compound from the Traditional Chinese Medicine (TCM) Chaihu-Shugan-San (CSS). Meranzin, isolated from leaves of Murraya exotica L., regulates the shared alpha 2-adrenoceptor and involves the AMPA-ERK1/2–BDNF signaling pathway. Meranzin has the potential for the prevention of the comorbidity of atherosclerosis and depression[1][2].

Name	8-{[(2S)-3,3-Dimethyl-2-oxiranyl]methyl}-7-methoxy-2H-chromen-2-o ne
Synonyms	pimelic acid monomethyl ester 8-{[(2S)-3,3-Dimethyl-2-oxiranyl]methyl}-7-methoxy-2H-chromen-2-one 6-methoxycarbonylhexanoic acid methyl hydrogenpimelate monomethyl heptanedioate Heptanedioic acid,1-methyl ester 2H-1-Benzopyran-2-one, 8-[[(2S)-3,3-dimethyloxiranyl]methyl]-7-methoxy- Heptanedioic acid,monomethyl ester Methyl hydrogen heptane-1,7-dioate Monomethyl pimelate

Description	Meranzin is an absorbed bioactive compound from the Traditional Chinese Medicine (TCM) Chaihu-Shugan-San (CSS). Meranzin, isolated from leaves of Murraya exotica L., regulates the shared alpha 2-adrenoceptor and involves the AMPA-ERK1/2–BDNF signaling pathway. Meranzin has the potential for the prevention of the comorbidity of atherosclerosis and depression[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Neurological Disease
References	[1]. Lan Li, et al. Chaihu-Shugan-San and Absorbed Meranzin Hydrate Induce Anti-Atherosclerosis and Behavioral Improvements in High-Fat Diet ApoE -/- Mice via Anti-Inflammatory and BDNF-TrkB Pathway. Biomed Pharmacother. 2019 Jul;115:108893. [2]. Rongwei Yan, et al. Preparative Isolation and Purification of Hainanmurpanin, Meranzin, and Phebalosin From Leaves of Murraya Exotica L. Using Supercritical Fluid Extraction Combined With Consecutive High-Speed Countercurrent Chromatography. J Sep Sci. 2018 May;41(9):2092-2101.

Hazard Codes	Xi

23971-42-8	1088-17-1
5875-49-0	54980-16-4