9000-69-5

9000-69-5 structure

Name: Pectin
Chemical Name: pectin
CAS Number: 9000-69-5
Molecular Formula: C₅H₁₀O₅
Molecular Weight: 150.130
Catalog: Biochemical Carbohydrate Polysaccharide
Create Date: 2018-02-07 08:00:00
Modify Date: 2024-01-02 12:13:13
Pectin is a heteropolysaccharide, derived from the cell wall of higher plants. Pectin involves in the formation of nanoparticles as a delivery vehicle of drugs. Pectin is also an adsorbent, a broad-spectrum antimicrobial agent that binds to bacteria toxins and other irritants in the intestinal mucosa, relieves irritated mucosa[1][2][3].

Name	pectin
Synonyms	gentisic acid dimethyl ether Dimethylaethergentisinsaeure 6-methoxy-m-anisic acid 2,5-dimethoxy-benzoic acid 2,5-dimethoxylbenzoic acid Benzoic acid,2,5-dimethoxy EINECS 232-553-0 2,5-Dimethoxy-benzoesaeure Pentose MFCD00081838 2,5-bis-methoxybenzoic acid GENU Pectin USP-H polygalacturonic acid

Description	Pectin is a heteropolysaccharide, derived from the cell wall of higher plants. Pectin involves in the formation of nanoparticles as a delivery vehicle of drugs. Pectin is also an adsorbent, a broad-spectrum antimicrobial agent that binds to bacteria toxins and other irritants in the intestinal mucosa, relieves irritated mucosa[1][2][3].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
Target	Human Endogenous Metabolite
In Vitro	Pectin (5 mg/mL; 24, 48, and 72 h) shows low cytotoxicity on HepG2 cells, and can be made into nanoparticles (PPN), encapsulating Paclitaxel (HY-B0015), decreases the Paclitaxel cytotoxicity (%) from 55.6% to 21.7% at 72 h[1]. Pectin (3, 6 mg/mL; 48 h) inhibits Staphylococcus aureus ATCC 25923 growth, with a minimum inhibitory concentration (MIC) of 40 mg/mL[2]. Pectin inhibits Gram-negative Helicobacter pylori, a common human pathogen, shows highest antibacterial activity at pH 5.0, with a minimum inhibitory concentration (MIC) of 0.162 mg/mL and minimum bactericidal concentration (MBC) of 0.325 mg/mL[2]. Pectin displays lower antibacterial activity against E. coli with MICs of 25 mg/mL and 50 mg/mL and MBC values ranging between 25-50 mg/mL[2]. Pectin exhibits the antibacterial activity via its undissociated acid form[2].
In Vivo	Pectin serves as the nanoparticles encapsulating Paclitaxel (HY-B0015), (20 mg/kg; i.v.; single dose) significantly delays plasma clearance with detection of Paclitaxel possible up to 48 h in Balb/c mice[1].
References	[1]. Verma AK, et al. Pharmacokinetics and biodistribution of negatively charged pectin nanoparticles encapsulating paclitaxel. Cancer Nanotechnol. 2013;4(4-5):99-102. [2]. Ciriminna R, et al. Pectin: A Long-Neglected Broad-Spectrum Antibacterial. ChemMedChem. 2020 Dec 3;15(23):2228-2235. [3]. Wikiera A, et al. Prozdrowotne właściwości pektyn [Health-promoting properties of pectin]. Postepy Hig Med Dosw (Online). 2014 Jan 2;68:590-6. Polish.

Density	1.5±0.1 g/cm3
Boiling Point	415.5±38.0 °C at 760 mmHg
Melting Point	6.1ºC
Molecular Formula	C₅H₁₀O₅
Molecular Weight	150.130
Flash Point	219.2±23.3 °C
Exact Mass	150.052826
PSA	97.99000
LogP	-2.39
Vapour Pressure	0.0±2.2 mmHg at 25°C
Index of Refraction	1.544
Storage condition	2-8°C
Water Solubility	H2O: soluble0.02g/10 mL, clear to hazy, colorless to very faintly yellow \| It is soluble in water.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RX4280000

CHEMICAL NAME :: Pectin

CAS REGISTRY NUMBER :: 9000-69-5

LAST UPDATED :: 199701

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 30 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FOREAE Food Research. (Champaign, IL) V.1-25, 1936-60. For publisher information, see JFDSAZ. Volume(issue)/page/year: 13,29,1948

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 56(1),58S,1960 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84368 No. of Facilities: 1645 (estimated) No. of Industries: 6 No. of Occupations: 13 No. of Employees: 16045 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7456 No. of Facilities: 1936 (estimated) No. of Industries: 9 No. of Occupations: 19 No. of Employees: 54050 (estimated) No. of Female Employees: 46189 (estimated)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases	S24/25
RIDADR	NONH for all modes of transport
RTECS	RX4280000
HS Code	1302200000

HS Code	1302200000

9000-69-5	56645-02-4
9005-59-8	65028-59-3
68916-88-1