Name | K-252a |
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Synonyms |
antibiotick252a
PROTEIN KINASE INHIBITOR FROM NORCARDIOP SIS SP. PROTEIN KINASE INHIBITOR K-252A PROTEIN KINASE INHIBITOR K252a K-252A,NOCARDIOPSIS SP K-252a Methyl (15S,16R,18R)-16-hydroxy-15-methyl-3-oxo-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1.0.0.0.0.0]octacosa-1,6,8,10,12,20,22,24,26-nonaene-16-carboxylate 6,9-Epoxy-15H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-7-carboxylic acid, 6,7,8,9,16,17-hexahydro-7-hydroxy-6-methyl-15-oxo-, methyl ester, (6S,7R,9R)- antibioticsf2370 sf2370 |
Description | K-252a, a staurosporine analog isolated from Nocardiopsis sp. soil fungi, inhibits protein kinase, with IC50 values of 470 nM, 140 nM, 270 nM, and 1.7 nM for PKC, PKA, Ca2+/calmodulin-dependent kinase type II, and phosphorylase kinase, respectively[1][2]. |
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Related Catalog | |
Target |
IC50: 470 nM (PKC), 140 nM (PKA), 270 nM (Ca2+/calmodulin-dependent kinase type II), 1.7 nM (phosphorylase kinase)[1][2]. |
References |
Density | 1.7±0.1 g/cm3 |
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Boiling Point | 685.3±55.0 °C at 760 mmHg |
Molecular Formula | C27H21N3O5 |
Molecular Weight | 467.473 |
Flash Point | 368.2±31.5 °C |
Exact Mass | 467.148132 |
PSA | 94.72000 |
LogP | 4.23 |
Vapour Pressure | 0.0±2.2 mmHg at 25°C |
Index of Refraction | 1.841 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
Symbol |
GHS08 |
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Signal Word | Danger |
Hazard Statements | H360D-H371 |
Precautionary Statements | P201-P260-P308 + P311 |
Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
Hazard Codes | Xi: Irritant; |
Safety Phrases | 22-24/25 |
RIDADR | NONH for all modes of transport |
RTECS | NZ0550000 |
Precursor 7 | |
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DownStream 2 | |