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  • Product Name: (R)-CR8
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Related CAS#:
294646-77-8 1786438-30-9
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294646-77-8

294646-77-8 structure
294646-77-8 structure
  • Name: (R)​-​CR8
  • Chemical Name: (2R)-2-[[9-propan-2-yl-6-[(4-pyridin-2-ylphenyl)methylamino]purin-2-yl]amino]butan-1-ol
  • CAS Number: 294646-77-8
  • Molecular Formula: C24H29N7O
  • Molecular Weight: 431.533
  • Catalog: Signaling Pathways Apoptosis Apoptosis
  • Create Date: 2017-09-16 10:57:22
  • Modify Date: 2024-01-09 14:54:22
  • (R)​-​CR8 (CR8), a second-generation analog of Roscovitine, is a potent CDK1/2/5/7/9 inhibitor. (R)​-​CR8 (CR8) inhibits CDK1/cyclin B (IC50=0.09 μM), CDK2/cyclin A (0.072 μM), CDK2/cyclin E (0.041 μM), CDK5/p25 (0.11 μM), CDK7/cyclin H (1.1 μM), CDK9/cyclin T (0.18 μM) and CK1δ/ε (0.4 μM). (R)​-​CR8 (CR8) induces apoptosis and has neuroprotective effect[1][2].
Name (2R)-2-[[9-propan-2-yl-6-[(4-pyridin-2-ylphenyl)methylamino]purin-2-yl]amino]butan-1-ol
Synonyms (2R)-2-[(9-Isopropyl-6-{[4-(2-pyridinyl)benzyl]amino}-9H-purin-2-yl)amino]-1-butanol
3ddp
CR-8
HMS3229B13
1-Butanol, 2-[[9-(1-methylethyl)-6-[[[4-(2-pyridinyl)phenyl]methyl]amino]-9H-purin-2-yl]amino]-, (2R)-
Description (R)​-​CR8 (CR8), a second-generation analog of Roscovitine, is a potent CDK1/2/5/7/9 inhibitor. (R)​-​CR8 (CR8) inhibits CDK1/cyclin B (IC50=0.09 μM), CDK2/cyclin A (0.072 μM), CDK2/cyclin E (0.041 μM), CDK5/p25 (0.11 μM), CDK7/cyclin H (1.1 μM), CDK9/cyclin T (0.18 μM) and CK1δ/ε (0.4 μM). (R)​-​CR8 (CR8) induces apoptosis and has neuroprotective effect[1][2].
Related Catalog
Target

Cdk1/cyclin B:0.09 μM (IC50)

cdk2/cyclin A:0.072 μM (IC50)

CDK2/cyclinE:0.041 μM (IC50)

Cdk5/p25:0.11 μM (IC50)

CDK7/cyclin H:1.1 μM (IC50)

CDK9/Cyclin T:0.18 μM (IC50)

CK1δ/ε:0.4 μM (IC50)
References

[1]. Bettayeb K, et al. CR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases. Oncogene. 2008 Oct 2;27(44):5797-807.

[2]. Kabadi SV, et al. CR8, a novel inhibitor of CDK, limits microglial activation, astrocytosis, neuronal loss, and neurologic dysfunction after experimental traumatic brain injury. J Cereb Blood Flow Metab. 2014 Mar;34(3):502-13.
Density 1.3±0.1 g/cm3
Boiling Point 671.4±65.0 °C at 760 mmHg
Molecular Formula C24H29N7O
Molecular Weight 431.533
Flash Point 359.8±34.3 °C
Exact Mass 431.243347
PSA 100.78000
LogP 2.10
Vapour Pressure 0.0±2.2 mmHg at 25°C
Index of Refraction 1.664
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Hazard Codes Xi
RIDADR NONH for all modes of transport
Precursor  2

DownStream  0


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title: CAS No. 294646-77-8 | Chemsrc address: https://www.chemsrc.com/en/baike/964830.html

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