36707-00-3

36707-00-3 structure

Name: API-1
Chemical Name: 4-amino-8-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-oxopyrido[2,3-d]pyrimidine-6-carboxamide
CAS Number: 36707-00-3
Molecular Formula: C₁₃H₁₅N₅O₆
Molecular Weight: 337.28800
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2017-05-08 22:20:33
Modify Date: 2025-08-24 18:36:47
API-1, a potent Akt/PKB inhibitor, binds to the PH domain and inhibits Akt membrane translocation. API-1 efficiently reduces the phosphorylation levels of Akt with an IC50 of ∼0.8 μM. API-1 is selective for PKB and does not inhibit the activation of PKC, and PKA. API-1 also induces apoptosis by synergizing with TNF-related apoptosis-inducing ligand (TRAIL)[1][2].

Name	4-amino-8-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-oxopyrido[2,3-d]pyrimidine-6-carboxamide
Synonyms	NSC 177223

Description	API-1, a potent Akt/PKB inhibitor, binds to the PH domain and inhibits Akt membrane translocation. API-1 efficiently reduces the phosphorylation levels of Akt with an IC50 of ∼0.8 μM. API-1 is selective for PKB and does not inhibit the activation of PKC, and PKA. API-1 also induces apoptosis by synergizing with TNF-related apoptosis-inducing ligand (TRAIL)[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> Akt
References	[1]. Donghwa Kim, et al. A small molecule inhibits Akt through direct binding to Akt and preventing Akt membrane translocation. J Biol Chem. 2016 Oct 21;291(43):22856. [2]. Donghwa Kim, et al. A small molecule inhibits Akt through direct binding to Akt and preventing Akt membrane translocation. J Biol Chem. 2016 Oct 21;291(43):22856.

36707-03-6

~28%

36707-00-3

Literature: LYNDOR BIOSCIENCES L.L.C.; AKINSANMI, Lawrence; KINCAID, John Patent: WO2012/158197 A2, 2012 ; Location in patent: Page/Page column 107 ;

36707-42-3

36707-00-3

Literature: LYNDOR BIOSCIENCES L.L.C.; AKINSANMI, Lawrence; KINCAID, John Patent: WO2012/158197 A2, 2012 ;

36707-43-4

36707-00-3

Literature: LYNDOR BIOSCIENCES L.L.C.; AKINSANMI, Lawrence; KINCAID, John Patent: WO2012/158197 A2, 2012 ;

Precursor 3
36707-03-6 36707-42-3 36707-43-4
DownStream 0