GL Biochem (Shanghai) Ltd.
China
Product Name: H-Nle-OH
Price: $Inquiry/1kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Jackie Yang

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: L-Norleucine
Price: ￥268.0/25g ￥888.0/100g
Purity: 97.0%
Stocking Period: Inquiry
Contact: Liu jia

Nanjing Peptide Biotech Ltd
China
Product Name: H-Nle-OH
Price: ￥Inquiry/10g ￥Inquiry/100g ￥Inquiry/1kg ￥Inquiry/10kg
Purity: 98.0%
Stocking Period: 7 Day
Contact: jom

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: L-Norleucine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

327-57-1

327-57-1 structure

327-57-1 structure

Name: L-Norleucine
Chemical Name: Hexanoic acid, 2-amino-, (S)
CAS Number: 327-57-1
Molecular Formula: C₆H₁₃NO₂
Molecular Weight: 131.173
Catalog: Biochemical Amino acids and their derivatives --amino acid
Create Date: 2018-02-14 08:00:00
Modify Date: 2024-01-02 10:21:42
L-Norleucine is an isomer of leucine, specifically affects protein synthesis in skeletal muscle, and has antivirus activity.

Name	Hexanoic acid, 2-amino-, (S)
Synonyms	L-2-Aminohexanoic acid EINECS 206-321-4 (S)-Norleucine Norleucine (S)-2-amino-Hexanoic acid (S)-(+)-2-Aminohexanoic acid H-L-NLE-OH Glycoleucine H-L-NORLEUCINE L-Norleucine (S)-(+)-2-Aminohexanoic acid (S)-2-Aminocaproic acid (S)-Aminohexanoic acid (S)-a-Aminocaproic acid L-2-Amino-hexanoic acid L-Aminohexanoic acid Norleucine, L- (S)-2-Aminohexanoic acid caprine H-NLE-OH H-ACPO(2)-OH L-2-aminohexanoate H-AHX(2)-OH D,L-Norleucine MFCD00064423 L(+)-Norleucine (S)-2-aminocaproic acid N-NORLEUCINE

Description	L-Norleucine is an isomer of leucine, specifically affects protein synthesis in skeletal muscle, and has antivirus activity.
Related Catalog	Research Areas >> Infection Natural Products >> Others
Target	Human Endogenous Metabolite
In Vitro	L-Norleucine is an isomer of leucine, specifically affecting protein synthesis in skeletal muscle[1]. L-Norleucine has antiviral activity. L-Norleucine interacts with hnRNPA2/B1 protein to suppresses the expressions of Twist1 and Snail, two inhibitors of E-cadherin, and promotes the expression of E-cadherin, resulting in the inhibition of tumor metastasis[2].
References	[1]. Schott KJ, et al. On the role of branched-chain amino acids in protein turnover of skeletal muscle. Studies in vivo with L-norleucine. Z Naturforsch C. 1985 May-Jun;40(5-6):427-37. [2]. He T, et al. The homeostasis-maintaining metabolites from bacterial stress response to bacteriophage infection suppress tumor metastasis. Oncogene. 2018 Jun 20.

Density	1.0±0.1 g/cm3
Boiling Point	234.0±23.0 °C at 760 mmHg
Melting Point	300ºC
Molecular Formula	C₆H₁₃NO₂
Molecular Weight	131.173
Flash Point	95.3±22.6 °C
Exact Mass	131.094635
PSA	63.32000
LogP	0.92
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.465

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RC6308000

CHEMICAL NAME :: Norleucine, L-

CAS REGISTRY NUMBER :: 327-57-1

BEILSTEIN REFERENCE NO. :: 1721750

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C6-H13-N-O2

MOLECULAR WEIGHT :: 131.20

WISWESSER LINE NOTATION :: ZY4&VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Microorganism - not otherwise specified

DOSE/DURATION :: 100 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 12,349,1971

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H317
Precautionary Statements	P280
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	R43
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	RC6308000
HS Code	29224995

Precursor 9
100516-59-4 625824-28-4 108488-49-9 7682-16-8
127644-00-2 625824-32-0 616-06-8 98891-36-2
108488-50-2
DownStream 10
3844-54-0 39608-30-5 60-35-5 110-62-3
6404-28-0 616-06-8 133388-96-2 158249-51-5
117903-25-0 1118-90-7

HS Code	2922499990
Summary	HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%