149-87-1

149-87-1 structure

Name: 5-Oxopyrrolidine-2-carboxylic acid
Chemical Name: 5-oxoproline
CAS Number: 149-87-1
Molecular Formula: C₅H₇NO₃
Molecular Weight: 129.114
Catalog: Biochemical Amino acids and their derivatives Glutamic acid derivative
Create Date: 2018-07-02 15:05:38
Modify Date: 2024-01-02 06:14:50
DL-Pyroglutamic acid (CAE) as an inactivator of hepatitis B surface, inactivates vaccinia virus, herpes simplex virus, and influenza virus except poliovirus. DL-Pyroglutamic acid is also a possible inhibitor of GABA transaminase, increases GABA amount with antiepileptic action[1][2].

Name	5-oxoproline
Synonyms	MFCD00064322 L-Pidolic acid H-DL-Pyr-OH DL-2-Pyrrolidone-5-carboxylic acid (S)-(-)-2-pyrrolidone-5-carboxylic acid Ajidew A 100 Pyrrolidonecarboxylic acid (S)-(-)-γ-Butyrolactam-γ-carboxylic acid PyroGlu L-Proline, 5-oxo- 5-Oxopyrrolidine-2-carboxylic Acid Pyroglutamic acid 2H-Pyrrole-2-carboxylic acid, 3,4-dihydro-5-hydroxy-, (2S)- L-5-Oxoproline DL-Pyroglutamic acid (S)-(−)-Pyroglutamic acid a-Aminoglutaric Acid Lactam 5-oxo-proline (S)-(−)-2-Pyrrolidone-5-carboxylic acid (-)-Pyroglutamic acid L-Glutamic Acid g-Lactam 5-Oxo-L-proline 5-Pyrrolidinone-2-carboxylic acid D,l-2-Pyrrolidone-5-Carboxylic Acid Proline, 5-oxo-, L- PCA Glutamic Acid Lactam 2-L-Pyrrolidone-5-carboxylic acid pidolic acid EINECS 205-748-3 (2S)-5-Hydroxy-3,4-dihydro-2H-pyrrole-2-carboxylic acid DL-Glutamic Acid Lactam 5-L-oxoproline 2-Pyrrolidone-5-carboxylic acid (S)-(-)-g-Butyrolactam-g-carboxylic Acid

Description	DL-Pyroglutamic acid (CAE) as an inactivator of hepatitis B surface, inactivates vaccinia virus, herpes simplex virus, and influenza virus except poliovirus. DL-Pyroglutamic acid is also a possible inhibitor of GABA transaminase, increases GABA amount with antiepileptic action[1][2].
Related Catalog	Signaling Pathways >> Anti-infection >> Influenza Virus Research Areas >> Infection Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Signaling Pathways >> Neuronal Signaling >> GABA Receptor
In Vitro	DL-Pyroglutamic acid results 50 and 100% inactivation of the antigen of 0.01-0.025% and 0.025-0.05%, respectively[1]. DL-Pyroglutamic acid is a possible glutamate antagonist, blocks glutamate miniature-end-plate potential in locust muscle-Druce and Bradford[2].
In Vivo	DL-Pyroglutamic acid (0.775 mM/L) completely abolishes the myoclonic jerks and EEG spikes in rats model of epileptic by cobalt implantation in the sensorimotor cerebral cortex[2].
References	[1]. Sugimoto Y, et al. N-alpha-Cocoyl-L-arginine ethyl ester, DL-pyroglutamic acid salt, as an inactivator of hepatitis B surface antigen. Antimicrob Agents Chemother. 1979 Sep;16(3):329-32.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S37/39
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	29337900