Name | Yohimbine hydrochloride |
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Synonyms |
UNII-NB2E1YP49F
Yohimbe HCl (16α,17α)-17-Hydroxyyohimban-16-carboxylate de méthyle chlorhydrate (1R,2S,4aR,13bS,14aS)-2-Hydroxy-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodécahydroindolo[2',3':3,4]pyrido[1,2-b]isoquinoléine-1-carboxylate de méthyle chlorhydrate Yohimbine hydrochloride Methyl (16α,17α)-17-hydroxyyohimban-16-carboxylate hydrochloride Methyl (16α,17α)-17-hydroxyyohimban-16-carboxylate hydrochloride (1:1) MFCD00012674 Yohimbine HCl Yohimban-16-carboxylic acid, 17-hydroxy-, methyl ester, (16α,17α)-, hydrochloride (1:1) Yohimban-16α-carboxylic acid, 17α-hydroxy-, methyl ester, monohydrochloride Antagonil Yohimban-16α-carboxylic acid, 17α-hydroxy-, methyl ester, monohydrochloride (8CI) Aphrodyne Methyl (1R,2S,4aR,13bS,14aS)-2-hydroxy-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydroindolo[2',3':3,4]pyrido[1,2-b]isoquinoline-1-carboxylate hydrochloride EINECS 200-600-4 Methyl-(1R,2S,4aR,13bS,14aS)-2-hydroxy-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydroindolo[2',3':3,4]pyrido[1,2-b]isochinolin-1-carboxylathydrochlorid Yohimbine monohydrochloride Yohimbine (Hydrochloride) |
Description | Yohimbine hydrochloride is an alpha 2-adrenoreceptor antagonist, blocking the pre- and postsynaptic alpha-2 adrenoreceptors and causing an increased release of noradrenaline and dopamine.IC50 value:Target:In vitro:In vivo: Yohimbine hydrochloride (0.2 mg/kg, i.p.) was administered to rats 1h before the stress session daily for 14 consecutive days and its effect was assessed. Results of this section revealed that, immersion of rats in cold water significantly decreased sexual arousal and motivation as indicated by increased latencies and intervals. Decreased copulatory activity was confirmed by decreased testosterone, luteinizing hormone (LH) and follicle-stimulating-hormone (FSH) levels as well as decreased cholesterol content in rat testes. Treatment with yohimbine significantly increased the sexual arousal and potency and corrected the effects induced by stress on the mating behavior of male rats [1]. |
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Related Catalog | |
References |
[1]. Saad MA, et al. Potential effects of yohimbine and sildenafil on erectile dysfunction in rats. |
Boiling Point | 542.979ºC at 760 mmHg |
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Melting Point | 288-290 °C (dec.)(lit.) |
Molecular Formula | C21H27ClN2O3 |
Molecular Weight | 390.904 |
Flash Point | 282.184ºC |
Exact Mass | 390.171021 |
PSA | 65.56000 |
LogP | 3.38700 |
Index of Refraction | 103 ° (C=1, H2O) |
Storage condition | 2~8°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
Symbol |
GHS06 |
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Signal Word | Danger |
Hazard Statements | H300-H311-H331 |
Precautionary Statements | P261-P264-P280-P301 + P310-P311 |
Personal Protective Equipment | Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges |
Hazard Codes | T |
Risk Phrases | R23/24;R33 |
Safety Phrases | S22-S36/37/39-S45-S24/25 |
RIDADR | UN 1544 6.1/PG 2 |
WGK Germany | 3 |
RTECS | ZG1015000 |
Packaging Group | II |
Hazard Class | 6.1(a) |
HS Code | 2933990090 |
HS Code | 2933990090 |
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Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |