120210-48-2
120210-48-2 structure
- Name: CP-66248
- Chemical Name: tenidap
- CAS Number: 120210-48-2
- Molecular Formula: C14H9ClN2O3S
- Molecular Weight: 320.75
- Catalog: API Antineoplastic agents Tinic antineoplastic agents
- Create Date: 2018-08-11 17:32:49
- Modify Date: 2025-08-26 09:24:43
-
Tenidap, a non-steroidal anti-inflammatory drug, is a selective COX-1 inhibitor, with IC50 values of 0.03 µM and 1.2 µM for COX-1 and COX-2, respectively. Tenidap has anti-inflammatory and antirheumatic properties[1][2].
| Name | tenidap |
|---|---|
| Synonyms |
TENIDAP
Tenidapum (3Z)-5-chloro-3-[hydroxy(thiophen-2-yl)methylidene]-2-oxoindole-1-carboxamide IL-6+Tenidap (3Z)-5-Chloro-2,3-dihydro-3-(hydroxy-2-thienylmethylene)-2-oxo-1H-indole-1-carboxamide CP 66248 |
| Description | Tenidap, a non-steroidal anti-inflammatory drug, is a selective COX-1 inhibitor, with IC50 values of 0.03 µM and 1.2 µM for COX-1 and COX-2, respectively. Tenidap has anti-inflammatory and antirheumatic properties[1][2]. |
|---|---|
| Related Catalog | |
| Target |
COX-1:0.03 μM (IC50) COX-2:1.2 μM (IC50) |
| References |
| Density | 1.58g/cm3 |
|---|---|
| Boiling Point | 523.9ºC at 760mmHg |
| Melting Point | 230° (dec) |
| Molecular Formula | C14H9ClN2O3S |
| Molecular Weight | 320.75 |
| Flash Point | 270.7ºC |
| Exact Mass | 320.00200 |
| PSA | 111.87000 |
| LogP | 4.01840 |
| Appearance | faint yellow to dark yellow |
| Vapour Pressure | 7.42E-13mmHg at 25°C |
| Index of Refraction | 1.756 |
| Storage condition | Store at +4°C |
| Water Solubility | DMSO: soluble1mg/mL, clear (warmed) |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Hazard Codes | Xn |
| Risk Phrases | 22 |
| RIDADR | NONH for all modes of transport |
| Precursor 6 | |
|---|---|
| DownStream 0 | |
![(Z)-5-chloro-3-[1-hydroxy-1-(2-thienyl)methylene]-2-oxo-1-phenoxycarbonyl-2,3-dihydroindole structure](https://image.chemsrc.com/caspic/383/255712-72-2.png)
![(Z)-5-chloro-3-[1-hydroxy-1-(2-thienyl)methylene]-1-methoxycarbonyl-2-oxo-2,3-dihydroindole structure](https://image.chemsrc.com/caspic/421/255712-71-1.png)
