118803-81-9

118803-81-9 structure

Name: quinoline-3-carboxylic acid
Chemical Name: 1-ethyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid,pyridine-3-carboxylic acid
CAS Number: 118803-81-9
Molecular Formula: C₂₂H₂₃FN₄O₅
Molecular Weight: 442.440
Catalog: Pharmaceutical intermediate Heterocyclic compound Quinoline compound
Create Date: 2018-02-04 08:00:00
Modify Date: 2024-01-10 15:50:37
Norfloxacin nicotinate (MK-0366 nicotinate) is a fluoroquinolones antibiotic, an adduct of Norfloxacin (NOR) and nicotinic acid. Norfloxacin nicotinate has been widely used for replacing NOR in animal husbandry and fishery industry. Norfloxacin nicotinate can induce innate immune response at a high concentration[1].

Name	1-ethyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid,pyridine-3-carboxylic acid
Synonyms	3-Pyridinecarboxylic acid, compd. with 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid (1:1) Norfloxacin nicotinate 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid - nicotinic acid (1:1) 1-Ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-1,4-dihydro-3-quinolinecarboxylic acid - nicotinic acid (1:1)

Description	Norfloxacin nicotinate (MK-0366 nicotinate) is a fluoroquinolones antibiotic, an adduct of Norfloxacin (NOR) and nicotinic acid. Norfloxacin nicotinate has been widely used for replacing NOR in animal husbandry and fishery industry. Norfloxacin nicotinate can induce innate immune response at a high concentration[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
In Vivo	Norfloxacin nicotinate (5 and/or 25 mg/L) significantly induces antioxidant enzymes activities and the mRNA levels of genes related to antioxidant enzymes and innate immune system in zebrafish larvae[1].
References	[1]. Liang X, et al. Effects of norfloxacin nicotinate on the early life stage of zebrafish (Danio rerio): Developmental toxicity, oxidative stress and immunotoxicity. Fish Shellfish Immunol. 2020 Jan;96:262-269.

Safety Phrases	S22
WGK Germany	3