870554-67-9

870554-67-9 structure

Name: GQ-16
Chemical Name: gq-16
CAS Number: 870554-67-9
Molecular Formula: C₁₉H₁₆BrNO₃S
Molecular Weight: 418.304
Catalog: Signaling Pathways Cell Cycle/DNA Damage PPAR
Create Date: 2017-04-12 11:41:24
Modify Date: 2024-01-04 11:02:36
GQ-16 is a moderate affinity ligand for the ligand-binding domain (LBD) of PPARγ, exhibiting a Ki of 160 nM. GQ-16 is an effective inhibitor of Cdk5-mediated phosphorylation of PPARγ. GQ-16 is a partial agonist of PPARγ with reduced adipogenic actions. GQ-16 promotes insulin Sensitization without weight gain[1].

Name	gq-16
Synonyms	(5Z)-5-(5-Bromo-2-methoxybenzylidene)-3-(4-methylbenzyl)-1,3-thiazolidine-2,4-dione 2,4-Thiazolidinedione, 5-[(5-bromo-2-methoxyphenyl)methylene]-3-[(4-methylphenyl)methyl]-, (5Z)-

Description	GQ-16 is a moderate affinity ligand for the ligand-binding domain (LBD) of PPARγ, exhibiting a Ki of 160 nM. GQ-16 is an effective inhibitor of Cdk5-mediated phosphorylation of PPARγ. GQ-16 is a partial agonist of PPARγ with reduced adipogenic actions. GQ-16 promotes insulin Sensitization without weight gain[1].
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> PPAR Research Areas >> Metabolic Disease
References	[1]. Angélica A Amato, et al. GQ-16, a novel peroxisome proliferator-activated receptor γ (PPARγ) ligand, promotes insulin sensitization without weight gain. J Biol Chem. 2012 Aug 10;287(33):28169-79.