- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: 5-Carboxy-8-hydroxyquinoline
- Price: Check
- Purity: 99.0%
- Stocking Period: 10 Day
- Contact: Yang
- Email: sales@echemcloud.com
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: 5-Carboxy-8-hydroxyquinoline
- Price: ￥3816.0/50mg ￥766.0/5mg ￥466.0/1mg ￥1046.0/10mg
- Purity: 95.0%
- Stocking Period: 1 Day
- Contact: Liu jia
- Email: 2130147988@qq.com
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: IOX1
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Stocking Period: 1 Day
- Contact: Tony Lai
- Email: order@dcchemicals.com
- DC Chemicals Limited
- China
- Product Name: IOX1
- Price: $300.0/100mg $600.0/250mg $1200.0/1g
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: 5-Carboxy-8-hydroxyquinoline
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
- Email: enquiry@dycnchem.com
- Shanghai Amole Biotechnology Co., Ltd.
- China
- Product Name: 5-Carboxy-8-hydroxyquinoline
- Price: ￥Inquiry/100mg ￥Inquiry/10mg ￥Inquiry/1g ￥Inquiry/1mg
- Purity: 99.0%
- Stocking Period: Inquiry
- Contact: Xiyao Wang
- Email: 3623107365@qq.com
5852-78-8
5852-78-8 structure
- Name: 5-Carboxy-8-hydroxyquinoline
- Chemical Name: 8-hydroxyquinoline-5-carboxylic acid
- CAS Number: 5852-78-8
- Molecular Formula: C10H7NO3
- Molecular Weight: 189.167
- Catalog: Biochemical Inhibitor Epigenetics Histone Demethylase Inhibitor
- Create Date: 2016-09-16 09:56:54
- Modify Date: 2025-09-01 21:17:25
-
IOX1 is the most potent broad-spectrum inhibitor of 2OG oxygenases, including the JmjC demethylases; IC50 for KDM4A/KDM3A is 0.6/0.1 uM.IC50 value: 0.6/0.1 uM(KDM4A/KDM3A) [1]Target: JmjC KDMs inhibitorIOX1 is the most potent against a representative panel of 2OG oxygenases, including non-JmjC 2OG oxygenases, with an in vitro IC50 value in the micromolar range. However, its efficacy in cells is about a hundred-fold lower (HeLa cells, KDM4A, IC50 = 86uM), possibly due to low cell permeability resulting from itspolar C-5 carboxyl group.
| Name | 8-hydroxyquinoline-5-carboxylic acid |
|---|---|
| Synonyms |
8XQ
8-Hydroxy-chinolin-5-carbonsaeure 5-Quinolinecarboxylic acid, 8-hydroxy- 8-hydroxy-quinoline-5-carboxylic acid UNII-JM015YQC1C 5-Carboxy-8-hydroxyquinoline IOX1 8-Hydroxy-5-quinolinecarboxylic acid |
| Description | IOX1 is the most potent broad-spectrum inhibitor of 2OG oxygenases, including the JmjC demethylases; IC50 for KDM4A/KDM3A is 0.6/0.1 uM.IC50 value: 0.6/0.1 uM(KDM4A/KDM3A) [1]Target: JmjC KDMs inhibitorIOX1 is the most potent against a representative panel of 2OG oxygenases, including non-JmjC 2OG oxygenases, with an in vitro IC50 value in the micromolar range. However, its efficacy in cells is about a hundred-fold lower (HeLa cells, KDM4A, IC50 = 86uM), possibly due to low cell permeability resulting from itspolar C-5 carboxyl group. |
|---|---|
| Related Catalog | |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 464.5±30.0 °C at 760 mmHg |
| Molecular Formula | C10H7NO3 |
| Molecular Weight | 189.167 |
| Flash Point | 234.7±24.6 °C |
| Exact Mass | 189.042587 |
| PSA | 70.42000 |
| LogP | 1.81 |
| Appearance | white to brown |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.730 |
| Storage condition | 2-8°C |
| Water Solubility | DMSO: soluble10mg/mL, clear |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Hazard Codes | Xn |
| Risk Phrases | 22 |
| RIDADR | NONH for all modes of transport |
| HS Code | 2933499090 |
|
~51%
5852-78-8 |
| Literature: Schiller, Rachel; Scozzafava, Giuseppe; Tumber, Anthony; Wickens, James R.; Bush, Jacob T.; Rai, Ganesha; Lejeune, Clarisse; Choi, Hwanho; Yeh, Tzu-Lan; Chan, Mun Chiang; Mott, Bryan T.; McCullagh, James S. O.; Maloney, David J.; Schofield, Christopher J.; Kawamura, Akane ChemMedChem, 2014 , vol. 9, # 3 p. 566 - 571 |
|
~49%
5852-78-8 |
| Literature: Sosic, Izidor; Mirkovic, Bojana; Arenz, Katharina; Stefane, Bogdan; Kos, Janko; Gobec, Stanislav Journal of Medicinal Chemistry, 2013 , vol. 56, # 2 p. 521 - 533 |
|
~%
5852-78-8 |
| Literature: Lippmann; Fleissner Chemische Berichte, 1886 , vol. 19, p. 2468 Monatshefte fuer Chemie, 1887 , vol. 8, p. 311 Full Text Show Details v. Niementowski; Sucharda Chemische Berichte, 1916 , vol. 49, p. 16 |
|
~%
5852-78-8 |
| Literature: Matsumura Journal of the American Chemical Society, 1935 , vol. 57, p. 124,127 |
|
~%
5852-78-8 |
| Literature: Matsumura Journal of the American Chemical Society, 1935 , vol. 57, p. 124,127 |
|
~%
5852-78-8 |
| Literature: v. Niementowski; Sucharda Chemische Berichte, 1916 , vol. 49, p. 16 |
|
~%
5852-78-8 |
| Literature: Clemo; Howe Journal of the Chemical Society, 1955 , p. 3552 |
|
~%
5852-78-8 |
| Literature: Clemo; Howe Journal of the Chemical Society, 1955 , p. 3552 |
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5852-78-8 |
| Literature: Clemo; Howe Journal of the Chemical Society, 1955 , p. 3552 |
| Precursor 7 | |
|---|---|
| DownStream 3 | |
| HS Code | 2933499090 |
|---|---|
| Summary | 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |