Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 4-Aminohex-5-ynoic acid
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DC Chemicals Limited
China
Product Name: γ-Acetylenic GABA
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: GAMMA-ACETYLENIC GABA
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Purity: 98.0%
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57659-38-8

57659-38-8 structure

57659-38-8 structure

Name: γ-Acetylenic GABA
Chemical Name: 4-aminohex-5-ynoic acid
CAS Number: 57659-38-8
Molecular Formula: C₆H₉NO₂
Molecular Weight: 127.14100
Catalog: Signaling Pathways Membrane Transporter/Ion Channel GABA Receptor
Create Date: 2017-03-21 10:31:52
Modify Date: 2025-08-27 16:49:11
γ-Acetylenic GABA (4-Aminohex-5-ynoic acid) is an irreversible inhibitor of GABA-transaminase. γ-Acetylenic GABA can increase the concentration of GABA in rat brain[1][2][3].

Name	4-aminohex-5-ynoic acid
Synonyms	5-Hexynoic acid,4-amino Acetylenic GABA-7 4-aminohexynoate

Description	γ-Acetylenic GABA (4-Aminohex-5-ynoic acid) is an irreversible inhibitor of GABA-transaminase. γ-Acetylenic GABA can increase the concentration of GABA in rat brain[1][2][3].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor
Target	GABA-transaminase[1]
In Vivo	γ-Acetylenic GABA (100 mg/kg i.p.) inhibits GABA-transaminase activity and causes a several-fold increase in the concentration of GABA in rat brain[2].
References	[1]. Casey DE, et, al. gamma-Acetylenic GABA in tardive dyskinesia. Arch Gen Psychiatry. 1980 Dec;37(12):1376-9. [2]. Palfreyman MG, et, al. The effect of gamma-acetylenic GABA, an enzyme-activated irreversible inhibitor of GABA-transaminase, on dopamine pathways of the extrapyramidal and limbic systems. Eur J Pharmacol. 1978 Aug 15;50(4):325-36. [3]. Alabed S, et, al. Gamma-aminobutyric acid agonists for neuroleptic-induced tardive dyskinesia. Cochrane Database Syst Rev. 2011 Apr 13;(4):CD000203.

Density	1.155g/cm3
Boiling Point	291.1ºC at 760 mmHg
Molecular Formula	C₆H₉NO₂
Molecular Weight	127.14100
Flash Point	129.8ºC
Exact Mass	127.06300
PSA	63.32000
LogP	0.51200
Index of Refraction	1.506

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MR0180450

CHEMICAL NAME :: 5-Hexynoic acid, 4-amino-

CAS REGISTRY NUMBER :: 57659-38-8

LAST UPDATED :: 199103

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C6-H9-N-O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 310 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - ptosis Behavioral - somnolence (general depressed activity) Skin and Appendages - hair

REFERENCE :: NEPHBW Neuropharmacology. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.9- 1970- Volume(issue)/page/year: 21,803,1982

Hazard Codes	Xi
Risk Phrases	36/37/38
Safety Phrases	26-36
HS Code	2922499990

57735-00-9 structure

57735-00-9

~%

57659-38-8 structure

57659-38-8

Literature: Metcalf,B.W.; Casara,P. Tetrahedron Letters, 1975 , p. 3337 - 3340

Precursor 1
57735-00-9
DownStream 1
89740-53-4

HS Code	2922499990
Summary	HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

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