Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Olmesartan
Price: ￥1748.0/500mg ￥578.0/100mg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Olmesartan
Price: $375.0/100mg $750.0/250mg $1500.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Olmesartan
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

144689-24-7

144689-24-7 structure

144689-24-7 structure

Name: Olmesartan
Chemical Name: olmesartan
CAS Number: 144689-24-7
Molecular Formula: C₂₄H₂₆N₆O₃
Molecular Weight: 446.502
Catalog: Signaling Pathways GPCR/G Protein Angiotensin Receptor
Create Date: 2018-07-10 18:41:40
Modify Date: 2024-01-02 18:00:19
Olmesartan is an angiotensin II receptor (AT1R) antagonist used to treat high blood pressure.

Name	olmesartan
Synonyms	4-(2-Hydroxy-2-propanyl)-2-propyl-1-{[2'-(1H-tetrazol-5-yl)-4-biphenylyl]methyl}-1H-imidazole-5-carboxylic acid Olmesartan Acid MFCD00914967 Olmesartan 5-(2-hydroxypropan-2-yl)-2-propyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carboxylic acid 1H-Imidazole-5-carboxylic acid, 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-

Description	Olmesartan is an angiotensin II receptor (AT1R) antagonist used to treat high blood pressure.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Angiotensin Receptor Research Areas >> Cardiovascular Disease
In Vivo	Repeated dosing of olmesartan (1 mg/kg, 2 mg/kg, p.o.) dose-dependently decreases mean arterial blood pressure (MAP) in SHR without significant influence on body weight and food intake during 10 weeks[1]. Olmesartan (5 mg/kg/d, p.o.) and Hyd treatments lower systolic blood pressure to the same degree in mice. Olmesartan treatment inhibits cardiac hypertrophy, evaluated by echocardiography, heart weight, cross-sectional area of cardiomyocytes, and gene expression. Olmesartan treatment reverses decreased gene expressions of ACE2 and Mas receptor of Ren-Tg mice and inhibits enhanced NADPH oxidase (Nox)4 expression and reactive oxygen species[2].
Animal Admin	Seven week-old male spontaneously hypertensive rats (SHR) are divided into five groups and fed a high fat diet (HFD) (60% kcal as fat) ad libitum. SHR are treated with vehicle (1% tragacanth gum solution), telmisartan (1 mg/kg), telmisartan (2 mg/kg), olmesartan (1 mg/kg) or olmesartan (2 mg/kg) once daily by gastric gavage. After more than 4 weeks-treatment, mean arterial blood pressure is measured for 24 h under a conscious state.
References	[1]. Yanagihara H, et al. Effects of telmisartan and olmesartan on insulin sensitivity and renal function in spontaneously hypertensive rats fed a high fat diet. J Pharmacol Sci. 2016 Jul;131(3):190-7. [2]. Tanno T, et al. Olmesartan Inhibits Cardiac Hypertrophy in Mice Overexpressing Renin Independently of Blood Pressure: Its Beneficial Effects on ACE2/Ang(1-7)/Mas Axis and NADPH Oxidase Expression. J Cardiovasc Pharmacol. 2016 Jun;67(6):503-9. [3]. Komiya H, et al. Sleep/wakefulness behaviors in mice during pregnancy and pregnancy-associated hypertensive mice. Sleep. 2018 Mar 1;41(3).

Density	1.3±0.1 g/cm3
Boiling Point	738.3±70.0 °C at 760 mmHg
Melting Point	186-188ºC
Molecular Formula	C₂₄H₂₆N₆O₃
Molecular Weight	446.502
Flash Point	400.3±35.7 °C
Exact Mass	446.206635
PSA	129.81000
LogP	3.72
Vapour Pressure	0.0±2.6 mmHg at 25°C
Index of Refraction	1.671
Storage condition	-20°C Freezer

Hazard Codes	Xi
RIDADR	NONH for all modes of transport
RTECS	NI4014100
HS Code	2921590090

HS Code	2921590090
Summary	2921590090. other aromatic polyamines and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%