Olmesartan

Modify Date: 2024-01-02 18:00:19

Olmesartan structure	Common Name	Olmesartan
	CAS Number	144689-24-7	Molecular Weight	446.502
	Density	1.3±0.1 g/cm3	Boiling Point	738.3±70.0 °C at 760 mmHg
	Molecular Formula	C₂₄H₂₆N₆O₃	Melting Point	186-188ºC
	MSDS	Chinese USA	Flash Point	400.3±35.7 °C

Use of Olmesartan

Olmesartan is an angiotensin II receptor (AT1R) antagonist used to treat high blood pressure.

Name	olmesartan
Synonym	More Synonyms

Description	Olmesartan is an angiotensin II receptor (AT1R) antagonist used to treat high blood pressure.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Angiotensin Receptor Research Areas >> Cardiovascular Disease
In Vivo	Repeated dosing of olmesartan (1 mg/kg, 2 mg/kg, p.o.) dose-dependently decreases mean arterial blood pressure (MAP) in SHR without significant influence on body weight and food intake during 10 weeks[1]. Olmesartan (5 mg/kg/d, p.o.) and Hyd treatments lower systolic blood pressure to the same degree in mice. Olmesartan treatment inhibits cardiac hypertrophy, evaluated by echocardiography, heart weight, cross-sectional area of cardiomyocytes, and gene expression. Olmesartan treatment reverses decreased gene expressions of ACE2 and Mas receptor of Ren-Tg mice and inhibits enhanced NADPH oxidase (Nox)4 expression and reactive oxygen species[2].
Animal Admin	Seven week-old male spontaneously hypertensive rats (SHR) are divided into five groups and fed a high fat diet (HFD) (60% kcal as fat) ad libitum. SHR are treated with vehicle (1% tragacanth gum solution), telmisartan (1 mg/kg), telmisartan (2 mg/kg), olmesartan (1 mg/kg) or olmesartan (2 mg/kg) once daily by gastric gavage. After more than 4 weeks-treatment, mean arterial blood pressure is measured for 24 h under a conscious state.
References	[1]. Yanagihara H, et al. Effects of telmisartan and olmesartan on insulin sensitivity and renal function in spontaneously hypertensive rats fed a high fat diet. J Pharmacol Sci. 2016 Jul;131(3):190-7. [2]. Tanno T, et al. Olmesartan Inhibits Cardiac Hypertrophy in Mice Overexpressing Renin Independently of Blood Pressure: Its Beneficial Effects on ACE2/Ang(1-7)/Mas Axis and NADPH Oxidase Expression. J Cardiovasc Pharmacol. 2016 Jun;67(6):503-9. [3]. Komiya H, et al. Sleep/wakefulness behaviors in mice during pregnancy and pregnancy-associated hypertensive mice. Sleep. 2018 Mar 1;41(3).

Density	1.3±0.1 g/cm3
Boiling Point	738.3±70.0 °C at 760 mmHg
Melting Point	186-188ºC
Molecular Formula	C₂₄H₂₆N₆O₃
Molecular Weight	446.502
Flash Point	400.3±35.7 °C
Exact Mass	446.206635
PSA	129.81000
LogP	3.72
Vapour Pressure	0.0±2.6 mmHg at 25°C
Index of Refraction	1.671
Storage condition	-20°C Freezer

Hazard Codes	Xi
RIDADR	NONH for all modes of transport
RTECS	NI4014100
HS Code	2921590090

HS Code	2921590090
Summary	2921590090. other aromatic polyamines and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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4-(2-Hydroxy-2-propanyl)-2-propyl-1-{[2'-(1H-tetrazol-5-yl)-4-biphenylyl]methyl}-1H-imidazole-5-carboxylic acid

Olmesartan Acid

MFCD00914967

Olmesartan

5-(2-hydroxypropan-2-yl)-2-propyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carboxylic acid

1H-Imidazole-5-carboxylic acid, 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Olmesartan
Price: ￥1748.0/500mg ￥578.0/100mg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Olmesartan
Price: $375.0/100mg $750.0/250mg $1500.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Olmesartan
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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