557-04-0

557-04-0 structure

Name: Magnesium stearate
Chemical Name: magnesium distearate
CAS Number: 557-04-0
Molecular Formula: C₃₆H₇₀MgO₄
Molecular Weight: 591.24
Catalog: Pharmaceutical intermediate Heterocyclic compound Pyridine compound Chloropyridine
Create Date: 2018-07-30 12:06:17
Modify Date: 2024-01-02 17:13:07
Magnesium stearate is a commonly used pharmaceutical lubricant. But Magnesium stearate leads to an adverse effect on bonding between particles. Magnesium stearate can be used as an excipient, such as lubricant. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1][2].

Name	magnesium distearate
Synonyms	MAGNESIUM DISTEARATE Magnesium stearate synpro 90 MFCD00036391 Stearic acid, magnesium salt MAGNESIUM STEARATE (E-470B, F.C.C.) ADITIO EINECS 209-150-3 Octadecanoic acid, magnesium salt stearic acid magnesium salt Octadecanoic acid, magnesium salt (2:1) stearatedemagnesium MAGENSIUM STEARATE MAGNESIUMSTEARATE MEGNESIUM STEATATE MAGNESIUMSTEARATEBP Magnesium dioctadecanoate Microcrystalline cellulose use as the oral steroid filler Dibasic magnesium stearate MAGNESIUM STEARATE API magnesiumdistearate Synpro Magnesium Stearate 90 OCTADECANOIC ACID MAGNESIUM SALT stearate magnesium Magnesiumdistearat MAGNESIUM STEARATE NF MAGNESIUM OCTADECANOATE magnesium sterate stearic acid,magnesium stearate Dolomol Magnesiumstearat OCTADECANOICACID, MAGNESIUM SALT (2:1) MAGNESIUMSTEARATE,FCC petracmg20nf MAGNESIUM STEARATE, FCC Magnesium Stearate Bp

Description	Magnesium stearate is a commonly used pharmaceutical lubricant. But Magnesium stearate leads to an adverse effect on bonding between particles. Magnesium stearate can be used as an excipient, such as lubricant. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1][2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. Zuurman K, et al. Effect of magnesium stearate on bonding and porosity expansion of tablets produced from materials with different consolidation properties[J]. International journal of pharmaceutics, 1999, 179(1): 107-115. [2]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25;87:88-99.

Density	1.028g/cm3
Boiling Point	359.4ºC at 760mmHg
Melting Point	200 °C(lit.)
Molecular Formula	C₃₆H₇₀MgO₄
Molecular Weight	591.24
Flash Point	162.4ºC
Exact Mass	590.512451
PSA	52.60000
LogP	12.50830
Index of Refraction	1.45 (25ºC)
Storage condition	Store at RT.
Stability	Stable. Incompatible with strong oxidizing agents.
Water Solubility	Insoluble

TOXIC EFFECTS :: Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

REFERENCE :: TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 17,51,1980 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 10 mg/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81884 No. of Facilities: 2092 (estimated) No. of Industries: 19 No. of Occupations: 34 No. of Employees: 31116 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6914 No. of Facilities: 64 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 320 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81884 No. of Facilities: 5057 (estimated) No. of Industries: 57 No. of Occupations: 78 No. of Employees: 184994 (estimated) No. of Female Employees: 101129 (estimated)

Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant
Risk Phrases	R36/37/38
Safety Phrases	S26-S37/39
RIDADR	NONH for all modes of transport
WGK Germany	-
RTECS	WI4390000
HS Code	29157030

69-65-8

557-04-0

Literature: US2014/100236 A1, ; Page/Page column ;

HS Code	29157030