Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 3,4,5-Trimethoxybenzoic acid 2-(dimethylamino)-2-phenylbutyl ester
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39133-31-8

39133-31-8 structure

Name: Trimebutine
Chemical Name: 3,4,5-Trimethoxybenzoic acid 2-(dimethylamino)-2-phenylbutyl ester
CAS Number: 39133-31-8
Molecular Formula: C₂₂H₂₉NO₅
Molecular Weight: 387.469
Catalog: API Anesthetic Agents Skeletal muscle relaxant
Create Date: 2018-07-25 17:34:38
Modify Date: 2024-01-02 13:33:43
Trimebutine is a drug with antimuscarinic and weak mu opioid agonist effects.Target: Opioid ReceptorTrimebutine is an agonist of peripheral mu, kappa and delta opiate receptors, used as spasmolytic agent for treatment of both acute and chronic abdominal pain [1]. The major product from drug metabolism of trimebutine in human beings is nor-trimebutine, which comes from removal of one of the methyl groups attached to nitrogen. Trimebutine exerts its effects in part due to causing a premature activation of phase III of the migrating motor complex in the digestive tract [2, 3].

Name	3,4,5-Trimethoxybenzoic acid 2-(dimethylamino)-2-phenylbutyl ester
Synonyms	trimebutine free base TRIMEBUTIN 3,4,5-TRIMETHOXYBENZOIC ACID 2-[DIMETHYLAMINO]-2-PHENYLBUTYL ESTER 3,4,5-TRIMETHOXYBENZOATE,-2'-PHENYL-2'-DIMETHYLAMINO-N-BUTYL Benzoic acid,3,4,5-trimethoxy-,2-(dimethylamino)-2-phenylbutyl ester (9CI) Trimebutine hydrochloride 2'-PHENYL-2'-DIMETHYLAMINO-N-BUTYL-3',4',5'-TRIMETHOXYBENZOATE 2-(Dimethylamino)-2-phenylbutyl 3,4,5-trimethoxybenzoate TRIMEBUTINE 3,4,5-Trimethoxybenzoic Acid 2-(Dimethylamino)-2-phenylbutyl Ester hydrogenated maleate of 2-dimethyl-amino-2-phenylbutyl-3,4,5-trimetoxybenzoate EINECS 254-309-2 MFCD00133873 TRIMEBUTINE3.4.5-TRIMETHOXYBENZOATE,-2'-PHENYL-2'-DIMETHYLAMINO-N-BUTYL Benzoic acid, 3,4,5-trimethoxy-, 2-(dimethylamino)-2-phenylbutyl ester trimebutine maleate

Description	Trimebutine is a drug with antimuscarinic and weak mu opioid agonist effects.Target: Opioid ReceptorTrimebutine is an agonist of peripheral mu, kappa and delta opiate receptors, used as spasmolytic agent for treatment of both acute and chronic abdominal pain [1]. The major product from drug metabolism of trimebutine in human beings is nor-trimebutine, which comes from removal of one of the methyl groups attached to nitrogen. Trimebutine exerts its effects in part due to causing a premature activation of phase III of the migrating motor complex in the digestive tract [2, 3].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Signaling Pathways >> Neuronal Signaling >> Opioid Receptor Research Areas >> Metabolic Disease
References	[1]. Kaneto, H., M. Takahashi, and J. Watanabe, The opioid receptor selectivity for trimebutine in isolated tissues experiments and receptor binding studies. J Pharmacobiodyn, 1990. 13(7): p. 448-53. [2]. Roman, F.J., et al., Pharmacological properties of trimebutine and N-monodesmethyltrimebutine. J Pharmacol Exp Ther, 1999. 289(3): p. 1391-7. [3]. Hiyama, T., et al., Effectiveness of prokinetic agents against diseases external to the gastrointestinal tract. J Gastroenterol Hepatol, 2009. 24(4): p. 537-46.

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2922199090

Precursor 1
557-04-0
DownStream 0

HS Code	2922199090
Summary	2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%