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74804-12-9

74804-12-9 structure
74804-12-9 structure
  • Name: Adenosine 5'-triphosphate magnesium salt
  • Chemical Name: [[5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate,magnesium
  • CAS Number: 74804-12-9
  • Molecular Formula: C10H14MgN5O13P3
  • Molecular Weight: 529.47000
  • Catalog: Research Areas Inflammation/Immunology
  • Create Date: 2018-10-02 21:21:43
  • Modify Date: 2024-01-05 19:31:34
  • ATP (Adenosine 5'-triphosphate) dimagnesium is a central component of energy storage and metabolism in vivo. ATP dimagnesium provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP dimagnesium is an important endogenous signaling molecule in immunity and inflammation[1][2].
Name [[5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate,magnesium
Synonyms Adenosine 5'-triphosphate magnesium salt
ATP magnesium salt
Adenosine 5 inverted exclamation marka-triphosphate magnesium salt
ATP-MG
Description ATP (Adenosine 5'-triphosphate) dimagnesium is a central component of energy storage and metabolism in vivo. ATP dimagnesium provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP dimagnesium is an important endogenous signaling molecule in immunity and inflammation[1][2].
Related Catalog
Target

Human Endogenous Metabolite

In Vitro ATP (5 mM; 1 hour) co-treatment with LPS (1 μg/mL) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs[3]. ATP (2 mM; 0.5-24 hours) induces secretion of IL-1β, KC and MIP-2 from BMDMs in a caspase-1 activation-dependent manner[4]. ATP promotes neutrophil chemotaxis in vitro[4].
In Vivo ATP (50 mg/kg; i.p.) protects mice against bacterial infection in vivo[4]. ATP induces the secretion of IL-1β, KC and MIP-2 and neutrophils recruitment in vivo[4]. Animal Model: Four-week-old Kunming mice (18-22 g)[4] Dosage: 50 mg/kg Administration: Intraperitoneal injection, before bacterial (E. coli) challenge Result: Protected mice from bacterial infection.
References

[1]. Swennen EL, et al. Immunoregulatory effects of adenosine 5'-triphosphate on cytokine release from stimulated whole blood. Eur J Immunol. 2005 Mar;35(3):852-8.

[2]. M J L Bours, et al. Adenosine 5'-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation. Pharmacol Ther. 2006 Nov;112(2):358-404.

[3]. Shuo Xu, et al. Doxycycline inhibits NAcht Leucine-rich repeat Protein 3 inflammasome activation and interleukin-1β production induced by Porphyromonas gingivalis-lipopolysaccharide and adenosine triphosphate in human gingival fibroblasts. Arch Oral Biol. 2019 Nov;107:104514.

[4]. Yang Xiang, et al. Adenosine-5'-Triphosphate (ATP) Protects Mice against Bacterial Infection by Activation of the NLRP3 Inflammasome. PLoS One. 2013; 8(5): e63759.
Molecular Formula C10H14MgN5O13P3
Molecular Weight 529.47000
Exact Mass 528.96500
PSA 314.22000
Storage condition 20°C
Symbol GHS08
GHS08
Signal Word Warning
Hazard Statements H371
Precautionary Statements P260
Hazard Codes Xn: Harmful;
Risk Phrases 20/21/22-68/20/21/22
Safety Phrases 36/37
RIDADR NONH for all modes of transport

Chemsrc provides CAS#:74804-12-9 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 74804-12-9 | Chemsrc address: https://www.chemsrc.com/en/baike/895065.html

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