71997-40-5

71997-40-5 structure

Name: ADENOSINE 5'-TRIPHOSPHATE,PERIODATE OXIDIZED SODIUM SALT
Chemical Name: ADENOSINE 5'-TRIPHOSPHATE, PERIODATE OXIDIZED SODIUM SALT
CAS Number: 71997-40-5
Molecular Formula: C₁₀H₁₁N₅Na₃O₁₃P₃
Molecular Weight: 571.11
Catalog: Signaling Pathways Immunology/Inflammation NOD-like Receptor (NLR)
Create Date: 2018-11-14 09:37:52
Modify Date: 2024-01-09 16:32:15
Oxidized ATP (oATP) trisodium salt is a broad-spectrum P2 receptor inhibitor. Oxidized ATP trisodium salt irreversibly antagonizes P2X7R activation. Oxidized ATP trisodium salt inhibits c-reactive protein (CRP)-induced NLRP3 inflammasome activation. Oxidized ATP trisodium salt can be used for research of atherosclerosis[1][2].

Name	ADENOSINE 5'-TRIPHOSPHATE, PERIODATE OXIDIZED SODIUM SALT
Synonyms	MFCD00056956

Description	Oxidized ATP (oATP) trisodium salt is a broad-spectrum P2 receptor inhibitor. Oxidized ATP trisodium salt irreversibly antagonizes P2X7R activation. Oxidized ATP trisodium salt inhibits c-reactive protein (CRP)-induced NLRP3 inflammasome activation. Oxidized ATP trisodium salt can be used for research of atherosclerosis[1][2].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> NOD-like Receptor (NLR) Research Areas >> Inflammation/Immunology Signaling Pathways >> Membrane Transporter/Ion Channel >> P2X Receptor
Target	NLRP3 inflammasome P2X7 Receptor
In Vivo	Oxidized ATP (300 μg/mouse, i.p., twice a week) trisodium salt ameliorates the induced mouse experimental autoimmune uveitis (EAU) in B6 mice[2]. Animal Model: Induced mouse experimental autoimmune uveitis (EAU)[2] Dosage: 300 μg/mouse Administration: i.p. Result: Showed almost undetected EAU, as shown by fundoscopic and pathologic examination. Decreased serum IL-17 level. Mitigated the autoreactive T cell response.
References	[1]. Bian F, et al. CRP-Induced NLRP3 Inflammasome Activation Increases LDL Transcytosis Across Endothelial Cells. Front Pharmacol. 2019 Jan 30;10:40. [2]. Zhao R, et al. Blockade of Extracellular ATP Effect by Oxidized ATP Effectively Mitigated Induced Mouse Experimental Autoimmune Uveitis (EAU). PLoS One. 2016 May 19;11(5):e0155953.

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