70588-05-5

70588-05-5 structure

Name: Obtusin
Chemical Name: Obtusin
CAS Number: 70588-05-5
Molecular Formula: C₁₈H₁₆O₇
Molecular Weight: 344.315
Catalog: Signaling Pathways Neuronal Signaling Monoamine Oxidase
Create Date: 2018-06-29 21:42:06
Modify Date: 2024-01-02 22:56:52
Obtusin, isolated from Cassia obtusifolia Linn seed, is a highly selective and competitive human monoamine oxidase-A (hMAO-A) inhibitor with an IC50 of 11.12 μM and a Ki of 6.15. Obtusin plays a preventive role in neurodegenerative diseases, especially anxiety and depression[1].

Name	Obtusin
Synonyms	9,10-Anthracenedione, 1,7-dihydroxy-2,3,8-trimethoxy-6-methyl- 1,7-dihydroxy-2,3,8-trimethoxy-6-methylanthracene-9,10-dione 1,7-Dihydroxy-2,3,8-trimethoxy-6-methyl-9,10-anthraquinone

Description	Obtusin, isolated from Cassia obtusifolia Linn seed, is a highly selective and competitive human monoamine oxidase-A (hMAO-A) inhibitor with an IC50 of 11.12 μM and a Ki of 6.15. Obtusin plays a preventive role in neurodegenerative diseases, especially anxiety and depression[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase Research Areas >> Neurological Disease
Target	IC50: 11.12 μM (hMAO-A)[1] Ki: 6.15 (hMAO-A)[1]
References	[1]. Paudel P, et al. In Vitro and in Silico Human Monoamine Oxidase Inhibitory Potential of Anthraquinones, Naphthopyrones, and Naphthalenic Lactones from Cassia obtusifolia Linn Seeds. ACS Omega. 2019 Sep 18;4(14):16139-16152.

HS Code	2914690090

108637-73-6

108637-94-1

~71%

70588-05-5

Literature: Cameron, Donald W.; Feutrill, Geoffrey I.; Gamble, Glenn B.; Stavrakis, John Tetrahedron Letters, 1986 , vol. 27, # 41 p. 4999 - 5002

Precursor 2
108637-73-6 108637-94-1
DownStream 0

HS Code	2914690090
Summary	2914690090 other quinones。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%