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138-60-3

138-60-3 structure
138-60-3 structure
Name Chelidamic acid
Synonyms Pd(OH)2/C
chelidamic acid
4-Hydroxypyridine-2,6-dicarboxylic Acid Monohydrate
4-oxo-1,4-dihydro-2,6-pyridinedicarboxylic acid
MFCD00066478
4-Hydroxy-2,6-pyridinedicarboxylic acid
4-oxo-1,4-dihydropyridine-2,6-dicarboxylic acid
4-PYRIDONE-2,6-DICARBOXYLIC ACID
1,4-dihydro-4-oxo-2,6-pyridinedicarboxylic acid
.HELIDAMIC AICD
2,6-Pyridinedicarboxylic acid, 1,4-dihydro-4-oxo-
CHELIDAMIC ACID HYDRATE
Chelidamaic acid
Chelidamic Acid Monohydrate
Chelidamic aicd
2,6-Pyridinedicarboxylic acid, 4-hydroxy-
Ammox-chelidonic acid
4-Hydroxypyridine-2,6-dicarboxylic acid
chelidamic acid approx.
EINECS 205-335-8
4-hydroxyl-pyridine-2,6-dicarboxylic acid
Description Chelidamic acid is a heterocyclic organic acid with a pyran skeleton. Chelidamic acid has good coordination ability with noble metal ions. Chelidamic acid is also one of the most potent inhibitors of glutamate decarboxylase, with a Ki of 33 μM.
Related Catalog
Target

Ki: 33 μM (Glutamate decarboxylase)[3].

In Vitro Chelidamic acid is a heterocyclic organic acid with a pyran skeleton[1]. Chelidamic acid has good coordination ability with noble metal ions[2]. Chelidamic acid is also one of the most potent inhibitors of glutamate decarboxylase, with a Ki of 33 μM[3].
References

[1]. Searcey M, et al. Synthesis, DNA-cleaving properties and cytotoxicity of intercalating chelidamic acid derivatives. Anticancer Drug Des. 13(8):837-55.

[2]. Espinet P, et al. Mesogenic palladium complexes with pincer ligands derived from dipicolinic acid. Inorg Chem. 2000 Aug, 7;39(16):3645-51.

[3]. Porter TG, et al. Chelidonic acid and other conformationally restricted substrate analogues as inhibitors of rat brain glutamate decarboxylase. Biochem Pharmacol. 1985 Dec 1;34(23):4145-50.
Density 1.7±0.1 g/cm3
Boiling Point 428.3±45.0 °C at 760 mmHg
Melting Point 267 °C (dec.)(lit.)
Molecular Formula C7H5NO5
Molecular Weight 183.118
Flash Point 212.8±28.7 °C
Exact Mass 183.016769
PSA 107.46000
LogP -1.43
Vapour Pressure 0.0±2.2 mmHg at 25°C
Index of Refraction 1.635
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S36
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2933399090
99-32-1 structure

99-32-1

~92%

138-60-3 structure

138-60-3

Literature: Horvath, Gyoergy; Rusa, Cristian; Koentoes, Zoltan; Gerencser, Janos; Huszthy, Peter Synthetic Communications, 1999 , vol. 29, # 21 p. 3719 - 3731
HS Code 2933399090
Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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