7365-45-9

7365-45-9 structure

Name: HEPES
Chemical Name: 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid
CAS Number: 7365-45-9
Molecular Formula: C₈H₁₈N₂O₄S
Molecular Weight: 238.305
Catalog: analytical chemistry Analytical reagent Ion chromatography reagent
Create Date: 2018-10-01 19:43:14
Modify Date: 2025-08-21 12:35:58
HEPES, a zwitterionic chemical buffering agent, is broadly applied in cell culture. HEPES is effective at pH 6.8 to 8.2. HEPES is a potent inducer of lysosome biogenesis[1][2][3].

Name	2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid
Synonyms	4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid hepesfreeacid 4-(2-Hydroxyethyl)piperazine-1-ethanesulfonic acid HEPES.1/2Na 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid EIT hydrobromide hepes solution 1-Piperazineethanesulfonic acid, 4-(2-hydroxyethyl)- 4-(2-hydroxyethyl)-1-piperazineethanesulphonic acid GOOD'S BUFFER HEPES HEPES BUFFER PH 8.0 2-[4-(2-Hydroxyethyl)-1-piperazinyl]ethanesulfonic acid EINECS 230-907-9 HEPES,1M solution MFCD00006158

Description	HEPES, a zwitterionic chemical buffering agent, is broadly applied in cell culture. HEPES is effective at pH 6.8 to 8.2. HEPES is a potent inducer of lysosome biogenesis[1][2][3].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. Suzuki T, et al. Nonvolatile buffer coating of titanium to prevent its biological aging and for drug delivery. Biomaterials. 2010;31(18):4818-4828. [2]. Sledź P, et al. An experimental charge density of HEPES. Acta Crystallogr B. 2010;66(Pt 4):482-492. [3]. Tol MJ, et al. HEPES activates a MiT/TFE-dependent lysosomal-autophagic gene network in cultured cells: A call for caution. Autophagy. 2018;14(3):437-449.

Density	1.3±0.1 g/cm3
Melting Point	234-238 °C
Molecular Formula	C₈H₁₈N₂O₄S
Molecular Weight	238.305
Exact Mass	238.098724
PSA	89.46000
LogP	-2.67
Index of Refraction	1.543
Storage condition	2-8°C
Stability	Stable. Combustible. Incompatible with strong oxidizing agents. Protect from moisture.
Water Solubility	Soluble

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1977- Volume(issue)/page/year: 6,149,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9468 No. of Facilities: 239 (estimated) No. of Industries: 2 No. of Occupations: 7 No. of Employees: 3025 (estimated) No. of Female Employees: 2233 (estimated)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S24/25-S22-S36-S26
RIDADR	NONH for all modes of transport
WGK Germany	1
RTECS	TL6809000
HS Code	29335995

HS Code	29335995