94596-26-6

94596-26-6 structure

Name: dynorphin (1-11), Pro(10)-
Chemical Name: α-Neoendorphin (swine), 7-L-arginine-8-L-isoleucine-8a-endo-L-arginine-9-D-proline
CAS Number: 94596-26-6
Molecular Formula: C₆₃H₁₀₃N₂₁O₁₃
Molecular Weight: 1362.62000
Catalog: Signaling Pathways GPCR/G Protein Adenylate Cyclase
Create Date: 2017-07-12 01:59:40
Modify Date: 2024-02-07 00:29:09
[DPro10] Dynorphin A (1-11), porcine, a N-Alkylated derivative, is a potent κ-opioid receptor agonist with a Ki value of 0.13 nM. [DPro10] Dynorphin A (1-11), porcine has analgesic property[1][2].

Name	α-Neoendorphin (swine), 7-L-arginine-8-L-isoleucine-8a-endo-L-arginine-9-D-proline
Synonyms	DYNORPHIN (1-11),PRO(10)- YGGFLRRIRDPK α-Neoendorphin (pig), 7-L-arginine-8-L-isoleucine-8a-endo-L-arginine-9-D-proline-

Description	[DPro10] Dynorphin A (1-11), porcine, a N-Alkylated derivative, is a potent κ-opioid receptor agonist with a Ki value of 0.13 nM. [DPro10] Dynorphin A (1-11), porcine has analgesic property[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Signaling Pathways >> GPCR/G Protein >> Adenylate Cyclase Signaling Pathways >> Neuronal Signaling >> Opioid Receptor Research Areas >> Neurological Disease
In Vitro	[DPro10] Dynorphin A (1-11), porcine has inhibition of adenylyl cyclase activity in k-opioid receptor-expressing CHO cells with an IC50 value of 0.12 nM[1].
In Vivo	[DPro10] Dynorphin A (1-11), porcine (ICV) has analgesic effects involving thermal cutaneous (tail-flick) and chemical visceral (AcOH-induced writhing) stimuli, in which mu and kappa receptors are known to be activated differentially[2].