123690-78-8

123690-78-8 structure

Name: CGP 36742
Chemical Name: 3-aminopropyl(n-butyl)-phosphinic acid
CAS Number: 123690-78-8
Molecular Formula: C₇H₁₈NO₂P
Molecular Weight: 179.19700
Catalog: Signaling Pathways Membrane Transporter/Ion Channel GABA Receptor
Create Date: 2017-07-23 00:34:24
Modify Date: 2025-08-25 09:53:34
CGP 36742 is a selective GABAB receptor antagonist that can penetrate the blood–brain barrier after peripheral administration, with an IC50 of 32 μM. CGP 36742 is useful in treatment of depression[1].

Name	3-aminopropyl(n-butyl)-phosphinic acid
Synonyms	3-aminopropyl-(n-butyl)-phosphinic acid (3-amino-propyl)-butyl-phosphinic acid (3-aminopropyl)(n-butyl)phosphinic acid 3-amino-propyl-n-butyl-phosphinic acid

Description	CGP 36742 is a selective GABAB receptor antagonist that can penetrate the blood–brain barrier after peripheral administration, with an IC50 of 32 μM. CGP 36742 is useful in treatment of depression[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor
Target	IC50: 32 μM (GABAB)[1]
References	[1]. Nowak G, et al. Antidepressant-like activity of CGP 36742 and CGP 51176, selective GABAB receptor antagonists, in rodents. Br J Pharmacol. 2006 Nov;149(5):581-90.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H319
Precautionary Statements	P305 + P351 + P338
Hazard Codes	Xi
RIDADR	NONH for all modes of transport
RTECS	SZ4113300