174545-76-7

174545-76-7 structure

Name: Eleutherobin
Chemical Name: eleutherobin
CAS Number: 174545-76-7
Molecular Formula: C₃₅H₄₈N₂O₁₀
Molecular Weight: 656.76300
Catalog: Signaling Pathways Cell Cycle/DNA Damage Microtubule/Tubulin
Create Date: 2017-05-01 20:20:14
Modify Date: 2024-01-09 17:37:09
Eleutherobin is a potent β-microtubule inhibitor with an IC50 value of 2 μM. Eleutherobin can be isolated from a marine soft coral. Eleutherobin has cytotoxic activity against cancer cells with similar potency to that of Paclitaxel (HY-B0015). Anticancer activity[1][2].

Name	eleutherobin
Synonyms	eleutherobin

Description	Eleutherobin is a potent β-microtubule inhibitor with an IC50 value of 2 μM. Eleutherobin can be isolated from a marine soft coral. Eleutherobin has cytotoxic activity against cancer cells with similar potency to that of Paclitaxel (HY-B0015). Anticancer activity[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin
Target	IC50: 2 μM (β-microtubule)[1]
In Vitro	Eleutherobin (0-600 nM; 72 h) exhibits cytotoxic activity against HCT116, HCT116 (VM46), A2780 and A2780/Tax22[1]. Cell Cytotoxicity Assay[1] Cell Line: HCT116, HCT116 (VM46), A2780 and A2780/Tax22 Concentration: 0-600 nM Incubation Time: 72 h Result: Exhibited cytotoxic activity against HCT116, HCT116 (VM46), A2780 and A2780/Tax22 with IC50s of 10.7 nM, 554 nM, 13.7 nM and 59 nM.
References	[1]. Long BH, et al. Eleutherobin, a novel cytotoxic agent that induces tubulin polymerization, is similar to paclitaxel (Taxol). Cancer Res. 1998 Mar 15;58(6):1111-5. [2]. Xiao-Nan Jia, et al. Deep Learning Promotes the Screening of Natural Products with Potential Microtubule Inhibition Activity. American Chemical Society. 2022