132173-06-9
132173-06-9 structure
- Name: SR-31747
- Chemical Name: N-[(Z)-3-(3-chloro-4-cyclohexylphenyl)prop-2-enyl]-N-ethylcyclohexanamine
- CAS Number: 132173-06-9
- Molecular Formula: C23H34ClN
- Molecular Weight: 359.97600
- Catalog: Research Areas Inflammation/Immunology
- Create Date: 2017-10-29 22:08:37
- Modify Date: 2025-11-15 21:16:17
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SR-31747 is a new sigma ligand with immunosuppressive properties.
| Name | N-[(Z)-3-(3-chloro-4-cyclohexylphenyl)prop-2-enyl]-N-ethylcyclohexanamine |
|---|---|
| Synonyms |
unii-g622f7p8lu
SR-31747 |
| Description | SR-31747 is a new sigma ligand with immunosuppressive properties. |
|---|---|
| Related Catalog | |
| In Vitro | SR-31747 is capable of inhibiting T-cell proliferation when added as late as 24 h after activation. SR-31747 arrests proliferation in yeast cells in a dose-dependent manner[2]. |
| In Vivo | SR 31747 dramatically blocks lipopolysaccharide-induced production of interleukin (IL)-1, IL-6 and tumor necrosis factor-alpha in a dose-dependent manner (ED50 2 mg/kg)[1]. |
| Animal Admin | IL-1, IL-6 and TNF-a are induced by i.p. injection of LPS into BALBIc mice. SR 31747 or reference substances are administered i.p. at the indicated doses together with LPS (0.5 mg/kg). Control animals are treated with LPS and vehicle. Blood samples are collected from the retro-orbital sinus 1 hr or 4 hr after LPS injection for the determination of TNF-α, IL-1 and IL-6. Plasma is prepared and stored frozen until experiments. The IL-1 plasma level is determined by a competitive radioreceptor assay with the use of the murine NOBEL4 cell line and [125I]-IL-1. The IL-6 assay is conducted with the B9 murine IL-6-dependent cell line. The TNF-a plasma level is evaluated by the cytolytic assay with the dactinomycin-treated LM6 cell line, derived from the murine fibroblastic L929 cell line. Each determination is performed on a pool of three different plasma samples. None of the molecules administered affect these assays even at the highest dose (10-5 M), which thereby rules out the possibility of any direct effect caused by the presence ofdrugs in treated-animal sera. In the various tests, one unit is defined as the amount of cytokines able to induce 50% of the maximal effect. |
| References |
| Molecular Formula | C23H34ClN |
|---|---|
| Molecular Weight | 359.97600 |
| Exact Mass | 359.23800 |
| PSA | 3.24000 |
| LogP | 7.05550 |