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332371-82-1

332371-82-1 structure
332371-82-1 structure
  • Name: 1,7-Bis(4-hydroxyphenyl)hepta-4,6-dien-3-one
  • Chemical Name: 1,7-bis(4-hydroxyphenyl)hepta-4,6-dien-3-one
  • CAS Number: 332371-82-1
  • Molecular Formula: C19H18O3
  • Molecular Weight: 294.34
  • Catalog: Natural product Phenols
  • Create Date: 2016-10-17 12:13:33
  • Modify Date: 2025-08-25 19:45:57
  • 1,7-Bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one (compound 6) shows antiproliferative activity with ED50s of 57.7, 78.8 µM for 26-L5 and HT-1080 cells, respectively. 1,7-Bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one inhibits melanogenesis in B16 melanoma 4A5 cells. 1,7-Bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one has the potential for the research of skin disorders[1][2].

Name 1,7-bis(4-hydroxyphenyl)hepta-4,6-dien-3-one
Synonyms 4,6-Heptadien-3-one, 1,7-bis(4-hydroxyphenyl)-, (4E,6E)-
(4E,6E)-1,7-Bis(4-hydroxyphenyl)-4,6-heptadien-3-one
Description 1,7-Bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one (compound 6) shows antiproliferative activity with ED50s of 57.7, 78.8 µM for 26-L5 and HT-1080 cells, respectively. 1,7-Bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one inhibits melanogenesis in B16 melanoma 4A5 cells. 1,7-Bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one has the potential for the research of skin disorders[1][2].
Related Catalog
In Vitro 1,7-Bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one (compound 2) (1-10 µM) inhibits melanogenesis in B16 melanoma 4A5 cells with an IC50 of 1.99 µM[2].
References

[1]. Ali MS, et al. Six new diarylheptanoids from the seeds of Alpinia blepharocalyx. J Nat Prod. 2001 Mar;64(3):289-93.

[2]. Matsumoto T, et al. Diarylheptanoids with inhibitory effects on melanogenesis from the rhizomes of Curcuma comosa in B16 melanoma cells. Bioorg Med Chem Lett. 2013 Sep 15;23(18):5178-81.

Density 1.2±0.1 g/cm3
Boiling Point 542.0±45.0 °C at 760 mmHg
Molecular Formula C19H18O3
Molecular Weight 294.34
Flash Point 295.7±25.2 °C
Exact Mass 294.125580
PSA 57.53000
LogP 2.89
Vapour Pressure 0.0±1.5 mmHg at 25°C
Index of Refraction 1.648
Hazard Codes Xi
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