DC Chemicals Limited
China
Product Name: SKF-81297 HBr
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: R(+)-6-CHLORO-7,8-DIHYDROXY-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROBROMIDE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

67287-39-2

67287-39-2 structure

67287-39-2 structure

Name: SKF 81297 hydrobromide
Chemical Name: (R)-6-Chloro-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol hydrobromide
CAS Number: 67287-39-2
Molecular Formula: C₁₆H₁₇BrClNO₂
Molecular Weight: 370.669
Catalog: Signaling Pathways GPCR/G Protein Dopamine Receptor
Create Date: 2018-12-28 13:18:29
Modify Date: 2024-01-04 13:35:08
SKF 81297 hydrobromide is a potent and selective dopamine D1 receptor agonist[1].

Name	(R)-6-Chloro-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol hydrobromide
Synonyms	R(+)-6-CHLORO-7,8-DIHYDROXY-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROBROMIDE 1H-3-Benzazepine-7,8-diol, 6-chloro-2,3,4,5-tetrahydro-1-phenyl-, (1R)-, hydrobromide (1:1) R-(+)-SKF-81297 hydrobromide (±)-6-Chloro-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide 6-Chloro-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol hydrobromide (1:1) 6-chloro-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide (1R)-6-Chloro-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol hydrobromide (1:1) Metastin (human) (R)-6-chloro-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol hydrobromide 1H-3-Benzazepine-7,8-diol, 6-chloro-2,3,4,5-tetrahydro-1-phenyl-, hydrobromide (1:1) (+/-)-6-chloro-2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine hydrobromide

Description	SKF 81297 hydrobromide is a potent and selective dopamine D1 receptor agonist[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease
Target	D1 Receptor
In Vivo	SKF 81297 hydrobromide (0.05-0.3 mg/kg，肌注，一次) 刺激 MPTP 损伤猴子的运动行为[1]。 Animal Model: Four male rhesus monkeys (Macaca mulatta, 7.0-11.3 kg)[1] Dosage: 0.05-0.3 mg/kg Administration: Injected intramuscularly (i.m.), once Result: Significantly increased rotational behaviour and right-sided hand use in unilateral MPTP-lesioned rhesus monkeys.
References	[1]. Vermeulen RJ, et al. The selective dopamine D1 receptor agonist, SKF 81297, stimulates motor behaviour of MPTP-lesioned monkeys. Eur J Pharmacol. 1993 Apr 22;235(1):143-7. [2]. Auger ML, et al. Amelioration of cognitive impairments induced by GABA hypofunction in the male rat prefrontal cortex by direct and indirect dopamine D1 agonists SKF-81297 and d-Govadine. Neuropharmacology. 2020 Jan 1;162:107844.

Molecular Formula	C₁₆H₁₇BrClNO₂
Molecular Weight	370.669
Exact Mass	369.013123
PSA	52.49000
LogP	4.31570

WGK Germany	3
HS Code	2933990090

Precursor 9
67287-38-1 621-59-0 67287-37-0 93983-14-3
5417-17-4 37687-57-3 67287-36-9 7537-07-7
93983-13-2
DownStream 0

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%