63335-24-0

63335-24-0 structure

Name: Malabaricone B
Chemical Name: 1-(2,6-dihydroxyphenyl)-9-(4-hydroxyphenyl)nonan-1-one
CAS Number: 63335-24-0
Molecular Formula: C₂₁H₂₆O₄
Molecular Weight: 342.43
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2017-10-01 06:48:51
Modify Date: 2025-08-24 21:43:22
Malabaricone B, a naturally occurring plant phenolic, is an orally active α-glucosidase inhibitor with an IC50 of 63.7 µM. Malabaricone B has anticancer, antimicrobial, anti-oxidation and antidiabetic activities[1][2][3].

Name	1-(2,6-dihydroxyphenyl)-9-(4-hydroxyphenyl)nonan-1-one
Synonyms	malabricone B Malabaricon B malabaricone B

Description	Malabaricone B, a naturally occurring plant phenolic, is an orally active α-glucosidase inhibitor with an IC50 of 63.7 µM. Malabaricone B has anticancer, antimicrobial, anti-oxidation and antidiabetic activities[1][2][3].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Research Areas >> Infection Research Areas >> Metabolic Disease
In Vitro	Malabaricone B shows selective toxicity to human lung cancer (A549), malignant melanoma (A375) and T cell leukemia (Jurkat) cell lines, without showing toxicity to human normal intestinal (INT407), human kidney (HEK293) and lung fibroblast (WI-38) cells. Among the chosen cancer cell lines, Malabaricone B shows maximum cytotoxicity to the A549 cells (IC50 = 8.1 μM), which is significantly better than that of curcumin (IC50 = 26.7 μM)[1]. The Malabaricone B-induced apoptosis is mediated by an increase in the intracellular reactive oxygen species (ROS). Malabaricone B (2.5, 5, 10 and 20 µM) increases the BAX level while simultaneously decreasing the BCL-2 and BCL-XL levels in the A549 cells, triggering the mitochondrial apoptotic pathway as revealed from the release of cytochrome c, and the activation of caspase-9 and caspase-3[1]. Malabaricone B exhibits a good level of antimicrobial activity when tested against avariety of microorganisms, including Staphylococcus aureus and Candida albicans[2].
In Vivo	Malabaricone B (100 mg/kg; p.o; alternate day, 23 days) inhibits lung tumor (xenograft) growth in SCID mice[1].
References	[1]. Mrityunjay Tyagi, et al. Spice-derived phenolic, malabaricone B induces mitochondrial damage in lung cancer cells via a p53-independent pathway. Food Funct. 2018 Nov 14;9(11):5715-5727. [2]. K Y Orabi, et al. Isolation and characterization of two antimicrobial agents from mace (Myristica fragrans). J Nat Prod. May-Jun 1991;54(3):856-9. [3]. B Prabha, et al. Antidiabetic potential of phytochemicals isolated from the stem bark of Myristica fatua Houtt. var. magnifica (Bedd.) Sinclair. Bioorg Med Chem. 2018 Jul 23;26(12):3461-3467.

Density	1.17g/cm3
Boiling Point	536.4ºC at 760 mmHg
Molecular Formula	C₂₁H₂₆O₄
Molecular Weight	342.43
Flash Point	292.3ºC
Exact Mass	342.18300
PSA	77.76000
LogP	4.95950
Index of Refraction	1.59

Precursor 4
699-83-2 54247-27-7 4047-24-9 71126-73-3
DownStream 0

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